川北医学院学报2024，Vol.39Issue(8)：1059-1063,5.DOI:10.3969/j.issn.1005-3697.2024.08.013
多巴丝肼联合重复经颅直流电刺激治疗对帕金森疾病患者运动和非运动功能的影响
Influence of levodopa and benserazide combined with repetitive transcrani-al direct current stimulation therapy on motor function and non-motor function in patients with Parkinson's disease
摘要
Abstract
Objective:To explore the influence of levodopa and benserazide combined with repetitive transcranial direct current stimulation(rTMS)on motor and non-motor functions in patients with Parkinson's disease(PD).Methods:96 patients with PD were selected as the research subjects,and they were divided into single group and combined group according to different treatment regimens,with 48 cases in each group.The single group was orally administered with levodopa and benserazide,while the combined group was giv-en rTMS therapy on this basis,the treatment course for both groups was 2 months.The clinical efficacy(UPDRS),and motor ability[Barthel index,muscle tension(MAS)],cognitive ability(MoCA),cerebral cortical excitability indicators[motor evoked potential(MEP),resting motor threshold(RMT)],quality of life(GQOL-74),and adverse reactions were compared between the two groups.Results:After treatment,the UPDRS,MAS and RMT in both groups were decreased(P＜0.05),and the above indicators in combined group were lower than those in single group(P＜0.05).The Barthel index,MoCA,MEP and GQOL-74 were increased in both groups(P＜0.05),and the combined group had higher indicators(P＜0.05).There were no significant differences in the incidence rates of adverse reactions between the two groups(P＞0.05).Conclusion:rTMS combined with levodopa and benserazide can improve the mo-tor function,cognitive function and cerebral cortical excitability and enhance the quality of life in patients with PD,and it has high safe-ty,which is worthy of clinical promotion.关键词
多巴丝肼/重复经颅直流电刺激/帕金森病/运动能力Key words
Levodopa and benserazide/Repetitive transcranial direct current stimulation/Parkinson's disease/Motor ability分类
医药卫生引用本文复制引用
康乐乐,苗婵婵,高海茸..多巴丝肼联合重复经颅直流电刺激治疗对帕金森疾病患者运动和非运动功能的影响[J].川北医学院学报,2024,39(8):1059-1063,5.基金项目
陕西省重点研发计划项目(S2021-YF-YBSF-0491) （S2021-YF-YBSF-0491）
