川北医学院学报2024，Vol.39Issue(8)：1064-1067,4.DOI:10.3969/j.issn.1005-3697.2024.08.014
血清ET-1、NT-proBNP、HIF-1α水平与急性左心衰竭患者预后的相关性
Correlation between serum ET-1,NT-proBNP,HIF-1α levels and prog-nosis of patients with acute heart failure
摘要
Abstract
Objective:To investigate the correlation between serum endothelin-1(ET-1),B-type natriuretic peptide precursor(NT-proBNP),hypoxia-inducible factor-1α(HIF-1α)levels and prognosis of patients with acute heart failure(AHF).Methods:108 patients with AHF were selected as the AHF group,and 100 healthy subjects were selected as the control group.The levels of serum ET-1,NT-proBNP and HIF-1α were detected in all subjects.The patients were divided into poor prognosis group(n=50)and good prognosis group(n=58)according to the occurrence of cardiovascular adverse events during the 1-year follow-up.Logistic regression model was used to analyze the prognostic factors of AHF patients,and the receiver operating characteristic(ROC)curve was used to e-valuate the prognostic predictive ability of each index.Results:The levels of serum ET-1,NT-proBNP and HIF-1α in AHF group were higher than those in control group(P＜0.05),and the levels of serum ET-1,NT-proBNP and HIF-1α gradually increased with the in-crease of cardiac function classification(P＜0.05).Compared with the good prognosis group,the levels of serum,ET-1,NT-proBNP and HIF-1α in the poor prognosis group were higher(P＜0.05).Logistic regression analysis showed that serum NT-proBNP(OR=1.273),ET-1(OR=1.365),HIF-1α(OR=1.670)were risk factors for poor prognosis in patients with AHF(P＜0.05).ROC curve analysis showed that serum ET-1,NT-proBNP and HIF-1α levels had certain predictive ability in predicting poor prognosis of patients,and their AUC were 0.751,0.730 and 0.744 respectively.The AUC of the combination of the three reached 0.862,which was higher than that of each single index(P＜0.05).Conclusion:Serum ET-1,NT-proBNP and HIF-1α levels are associated with cardiac function classification and prognosis in patients with AHF.All three can be used as prognostic reference indicators,and com-bined application can improve the predictive ability of poor prognosis.关键词
急性左心衰竭/预后/内皮素1/N端B型钠尿肽前体/缺氧诱导因子1αKey words
Acute left heart failure/Prognosis/Endothelin-1/B-type natriuretic peptide precursor/Hypoxia-inducible factor-1α分类
医药卫生引用本文复制引用
吴倩,杨娟,孙斌..血清ET-1、NT-proBNP、HIF-1α水平与急性左心衰竭患者预后的相关性[J].川北医学院学报,2024,39(8):1064-1067,4.基金项目
安徽省卫生健康科研项目(AHWJ2022c056) （AHWJ2022c056）
