川北医学院学报2024，Vol.39Issue(8)：1076-1079,4.DOI:10.3969/j.issn.1005-3697.2024.08.017
原发性高血压患者TyG指数与血压变异性及亚临床靶器官损伤的相关性
Correlation between the TyG index and blood pressure variability and subclinical target organ damage in patients with essential hypertension
摘要
Abstract
Objective:To explore the association between the triglyceride glucose(TyG)index and blood pressure variability(BPV),as well as subclinical target organ damage(STOD),in patients with essential hypertension(EH).Methods:All 226 EH pa-tients were ambulatorized blood pressure monitors,collected 24 h real-time blood pressure,and examined subclinical target organs at the same time.According to the examination results,STOD was defined as STOD group(n=107).Those who did not develop STOD were classified into NSTOD group(n=119).Univariate and Logistic regression analysis was used to analyze the factors influencing the oc-currence of STOD in EH patients,and Pearson correlation was used to analyze the correlation between TyG index and BPV.Results:Through single factor analysis,disease course,triglycerides(TG),fasting blood glucose(FBG),fasting insulin(FINS),glycated hemo-globin(HbA1C),TyG index,urinary microalbumin to creatinine ratio(ACR),left ventricular mass index(LVMI),arm ankle pulse wave velocity(baPWV),24 h diastolic blood pressure(SBP)standard deviation(24 h SSD),daytime SBP standard deviation(dSSD),nighttime SBP standard deviation(nSSD),24 hour SBP coefficient of variation(24 h SCV),daytime SBP coefficient of varia-tion(dSCV),SBP weighted standard deviation(SBPWSD),SBP actual mean of variation(SBPARV)levels,and nocturnal blood pres-sure drop rate were the relevant factors affecting STOD in EH(P＜0.05).Logistic regression equation analysis showed that TyG index,24 h SSD and d SSD were risk factors for STOD in EH patients(P＜0.05).Pearson correlation analysis showed that TyG index was positively correlated with 24 h SSD and d SSD expression in BPV(P＜0.05).Conclusion:Increased expression levels of TyG index,along with 24 h SSD and d SSD within BPV parameters emerged as risk factors influencing STOD development in EH patients,thus early monitoring can aid clinicians in assessing patient condition.关键词
原发性高血压/甘油三酯葡萄糖指数/血压变异性/亚临床靶器官损伤/相关性Key words
Essential hypertension/Triglyceride glucose index/Blood pressure variability/Subclinical target-organ damages/Cor-relation分类
医药卫生引用本文复制引用
谭健锋,胡亦懿,胡允兆..原发性高血压患者TyG指数与血压变异性及亚临床靶器官损伤的相关性[J].川北医学院学报,2024,39(8):1076-1079,4.基金项目
广东省中医药局科研项目(20241313) （20241313）
