川北医学院学报2024，Vol.39Issue(8)：1085-1088,4.DOI:10.3969/j.issn.1005-3697.2024.08.019
左乙拉西坦联合奥卡西平治疗癫痫患儿疗效及其对脑损伤指标的影响
Efficacy of levetiracetam combined with oxcarbazepine on children with epilepsy and its influence on brain injury degree
摘要
Abstract
Objective:To explore the therapeutic effect of levetiracetam(LEV)combined with oxcarbazepine(OXC)on epilep-sy in children.Methods:113 children with epilepsy were selected as the research subjects.They were divided into combined group(n=56)and single drug group(n=57)according to different treatment methods.The combined group was treated with LEV and OXC,and the single drug group was treated with OXC.The clinical efficacy,epilepsy attack,brain injury[amplitude-integrated electro-encephalogram(aEEG),S-100 beta protein(S-100β),glial fibrillary acidic protein(GFAP)],cognitive function[Wechsler Intelli-gence Scale for Children(WISC-CR)],inflammatory factors and complications were compared between the two groups.Results:After 6 months of treatment,the clinical efficacy of children in combined group was higher(P＜0.05).The attack frequency,duration,modified aEEG score,S-100[3,GFAP and inflammatory factors in both groups of children were decreased(P＜0.05),and the above indicators were lower in combined group(P＜0.05).The WISC-CR scores were increased in both groups of children(P＜0.05),and the com-bined group had higher WISC-CR scores(P＜0.05).There were no statistical differences in the incidence rates of complications be-tween groups(P＞0.05).Conclusion:LEX combined with OXC treatment in children with epilepsy significantly improves brain tissue damage and contributes to the recovery of cognitive function in children with epilepsy,with a good therapeutic effect and high safety.关键词
癫痫/左乙拉西坦/奥卡西平/改良振幅整合脑电图评分/认知功能Key words
Epilepsy/Levetiracetam/Oxcarbazepine/Modified amplitude integrated electroencephalogram score/Cognitive func-tion分类
医药卫生引用本文复制引用
张冬艳,李彤,张丽娜,王雪勤,王建忠,李学超,张芳..左乙拉西坦联合奥卡西平治疗癫痫患儿疗效及其对脑损伤指标的影响[J].川北医学院学报,2024,39(8):1085-1088,4.基金项目
河北省秦皇岛市重点研发计划科技支撑项目(202101A094) （202101A094）
