长春中医药大学学报2024，Vol.40Issue(7)：787-790,4.DOI:10.13463/j.cnki.cczyy.2024.07.018
血清HIF-1α及SP-D在儿童咳嗽变异性哮喘中的诊断意义
Diagnostic significance of serum hypoxia-inducible factor 1α and surfactant associated protein D in childhood cough variant asthma
摘要
Abstract
Objective To explore the diagnostic significance of serum hypoxia-inducible factor 1α(HIF-1α)and surfactant associated protein D(SP-D)in childhood cough variant asthma(CVA).Methods A total of 80 children with CVA admitted to Hainan Modern Women and Children's Hospital from January 2020 to December 2021 were selected as the reseach subjects,and 80 children who underwent health examinations during the same period were selected as the control group.The serum levels of HIF-1α and SP-D of the children were measured by enzyme-linked immunosorbent assay,and the pulmonary ventilation function of the children was also measured.Results Compared with the control group,the serum levels of HIF-1α and SP-D in the CVA group increased(P＜0.05).Forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)in the CVA group were lower than those in the control group.There was no significant correlation between HIF-1α and SP-D levels and FVC,FEV1 and FEV1/FVC in the CVA group.Conclusion The serum levels of HIF-1α and SP-D can be used as auxiliary indicators for the diagnosis of childhood CVA.关键词
儿童/变异性哮喘/HIF-1α/SP-DKey words
children/cough variant asthma/hypoxia-inducible factor 1α/surfactant associated protein D分类
医药卫生引用本文复制引用
林蓉,林秋,杨庆红,郑祝龄..血清HIF-1α及SP-D在儿童咳嗽变异性哮喘中的诊断意义[J].长春中医药大学学报,2024,40(7):787-790,4.基金项目
海南省卫生健康行业科研项目(20A200037) （20A200037）
