磁共振成像2024，Vol.15Issue(6)：153-158,6.DOI:10.12015/issn.1674-8034.2024.06.024
动态功能连接在孤独症谱系障碍中的应用及研究进展
Dynamic functional connectivity in autism spectrum disorders: applications and research advances
摘要
Abstract
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder resulting from impaired information flow in human brain systems, highly heritable and associated with impaired dynamic functional connectivity (DFC). Individuals with ASD are one of the more far-reaching child psychiatric disorders, and the families of diagnosed children are faced with multiple stressors and challenges from financial, emotional, and social perspectives. Previous research on ASD has been based on resting-state functional connectivity (SFC), but SFC has largely failed to take into account the presence and potential of temporal variability to impact brain function. In recent years, DFC has been widely used in ASD studies because it can accurately capture the fluctuations of functional connectivity (FC) over time and reveal the transitions between different FC states. In this paper, we review some common and newer methods of DFC, such as the sliding-window (SW) , the hidden Markov model (HMM), and the leading eigenvector dynamics analysis (LEiDA), as well as the applications and recent research progress of these methods in ASD, and summarize and compare the advantages and shortcomings of these methods. This review expects to provide a new way for early diagnosis and personalized treatment of ASD by summarizing the DFC methods and their applications. By analyzing DFC patterns, researchers are able to identify specific connective features associated with ASD, and are expected to develop DFC-based biomarkers to improve the diagnostic accuracy and reliability of ASD.关键词
孤独症谱系障碍/磁共振成像/功能磁共振成像/脑网络/功能网络/动态功能连接Key words
autism spectrum disorder/magnetic resonance imaging/functional magnetic resonance imaging/brain network/functional network/dynamic functional connectivity分类
医药卫生引用本文复制引用
伍光榕,张国敏,许媛媛,杨伟..动态功能连接在孤独症谱系障碍中的应用及研究进展[J].磁共振成像,2024,15(6):153-158,6.基金项目
遵义市科技计划项目[编号:遵市科合HZ字[2020]125号、遵市科合HZ字[2023]491号]Zunyi Science and Technology Plan Project (No.Zun Shi Ke He HZ [2020] 125, Zun Shi Ke He HZ [2023] 491). （No.Zun Shi Ke He HZ [2020] 125, Zun Shi Ke He HZ [2023] 491）
