重庆医学2024，Vol.53Issue(13)：2047-2052,6.DOI:10.3969/j.issn.1671-8348.2024.13.023
PI3K/Akt/mTOR信号通路与自噬调控及相关疾病关系
Relationship between PI3K/Akt/mTOR signal pathway and autophagy regulation and related diseases
摘要
Abstract
Phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamy-cin(mTOR)signaling pathway is an important regulating pathway for metabolism,proliferation and survival in cells,and plays a pivotal role in maintaining cellular homeostasis.This signaling pathway participates in the occurrence and development process of multiple diseases by mediating the cellular autophagy,such as tumors,neurodegenerative disorders(ND)and metabolic diseases.This paper reviews the role of PI3K/Akt/mTOR signaling pathway in autophagy regulation in order to better understand the regulatory mechanisms of cellular metabolism and survival,moreover investigate the role of this signal pathway in multiple diseases and direc-tion of the future study to provide reference for explore the new disease treatment methods.关键词
PI3K/Akt/mTOR信号通路/自噬/疾病/综述Key words
PI3K/Akt/mTOR signaling pathway/autophagy/disease/review分类
医药卫生引用本文复制引用
李卫胜,王婷婷,何文强..PI3K/Akt/mTOR信号通路与自噬调控及相关疾病关系[J].重庆医学,2024,53(13):2047-2052,6.基金项目
国家自然科学基金项目(82004311) （82004311）
河南省中医药科学研究专项课题(2022JDZX026). （2022JDZX026）
