南方医科大学学报2024，Vol.44Issue(7)：1266-1271,6.DOI:10.12122/j.issn.1673-4254.2024.07.06
甘油三酯-葡萄糖指数与非肥胖型非酒精性脂肪性肝病的相关性
Triglyceride-glucose index in non-obese individuals:its association with and predictive value for non-alcoholic fatty liver disease
摘要
Abstract
Objective To investigate the association of triglyceride-glucose index(TyG)with non-alcoholic fatty liver disease(NAFLD)and its diagnostic value for NAFLD in non-obese individuals.Methods We retrospectively collected the data of non-obese individuals(BMI<25 kg/m2)undergoing routine health examination at Second Affiliated Hospital of Xi'an Jiaotong University between May,2020 and December,2023,who all received abdominal ultrasound examination for NAFLD screening.The nonlinear relationship between TyG and non-obese NAFLD was explored using restricted cubic splines(RCS),and LASSO regression was used for variable screening;the correlation between TyG and NAFLD risk was analyzed using multivariate logistic regression.The diagnostic value of TyG for non-obese NAFLD was assessed using receiver-operating characteristic(ROC)curves and sensitivity analysis.Results A total of 3723 non-obese subjects were enrolled in this study,including 432(11.6%)patients with NAFLD.Compared with the healthy individuals,the patients with NAFLD had significant elevations of systolic and diastolic blood pressures,total cholesterol,triglycerides,LDL-C,blood uric acid,fasting blood glucose,and TyG index and a decreased HDL-C level(P<0.05).Multivariate logistic regression revealed that for each one-unit increase of TyG,the risk of non-obese NAFLD increased by 2.2 folds(OR=3.22,95%CI:2.53-4.12,P<0.001).Compared with a TyG index in the lowest quartile Q1,a TyG index in the Q2,Q3 and Q4 quartiles was associated with an increased risk of NAFLD by 1.52 folds(OR=2.52,95%CI:1.20-5.95),3.56 folds(OR=4.56,95%CI:2.28-10.46),and 8.66-folds(OR=9.66,95%CI:4.83-22.18),respectively.The RCS curve demonstrated a significant linear correlation between TyG index and non-obese NALFD risk(P for nonlinear=0.019).For diagnosing non-obese NALFD,TyG index had an area under ROC curve of 0.819 with a sensitivity of 78.0%and a specificity of 71.2%.Conclusion An increase of TyG index is correlated with increased risks of NAFLD in non-obese individuals and can serve as an indicator for screening early NAFLD in healthy individuals.关键词
非肥胖型脂肪肝/甘油三酯-葡萄糖指数/血脂异常/胰岛素抵抗Key words
non-obese non-alcoholic fatty liver disease/triglyceride-glucose index/dyslipidemia/insulin resistance引用本文复制引用
肖静,李盈,方敏,巩红,李文,张春艳,陈方尧,张岩,韩拓..甘油三酯-葡萄糖指数与非肥胖型非酒精性脂肪性肝病的相关性[J].南方医科大学学报,2024,44(7):1266-1271,6.基金项目
国家自然科学基金青年项目(82100359) （82100359）
陕西省自然科学基金一般项目(2020JQ-552 （）
2023-JC-YB-709) Supported by Youth Program of National Natural Science Foundation of China(82100359). （82100359）
