南方医科大学学报2024，Vol.44Issue(7)：1397-1406,10.DOI:10.12122/j.issn.1673-4254.2024.07.20
肠道菌群与色素沉着绒毛结节性滑膜炎之间的因果关系:基于孟德尔随机化分析
Causal relationship between gut microbiota and pigmented villonodular synovitis:a Mendelian randomization analysis
摘要
Abstract
Objective To investigate the causal relationship between gut microbiota and pigmented villonodular synovitis using Mendelian randomization analysis.Methods We conducted a two-sample Mendelian randomization analysis to investigate the causal relationship between 211 gut microbiome taxa and pigmented villonodular synovitis based on GWAS summary data,with inverse variance weighted(IVW)analysis as the primary result and the other methods as supplementary analyses.The reliability of the results was tested using Cochran's Q test,MR-Egger regression,MR-PRESSO method and conditional Mendelian randomization analysis(cML-MA).Results The increased abundance of Barnesiella(OR=3.12,95%CI:1.15-8.41,P=0.025)and Rumatococcaceae UCG010(OR=4.03,95%CI:1.19-13.68,P=0.025)may increase the risk of pigmented villous nodular synovitis,and elevated abundance of Lachnospiraceae(OR=0.33,95%CI:0.12-0.91,P=0.032),Alistipes(OR=0.16,95%CI:0.05-0.53,P=0.003),Blautia(OR=0.20,95%CI:0.06-0.61,P=0.005),and Lachnospiraceae FCS020 group(OR=0.38,95%CI:0.15-0.94,P=0.036)and Ruminococcaceae UCG014(OR=0.36,95%CI:0.14-0.94,P=0.037)were all associated with a reduced risk of pigmented villonodular synovitis,which were supported by the results of sensitivity analyses.Reverse Mendelian randomization analysis did not reveal any inverse causal association.Conclusion Increased abundance of specific intestinal microorganisms is associated with increased or decreased risks of developing hyperpigmented villonodular synovitis,and gut microbiota plays an important role in the pathogenesis of this disease.关键词
肠道菌群/色素沉着绒毛结节性滑膜炎/孟德尔随机化/因果关系Key words
gut microbiota/pigmented villonodular synovitis/Mendelian randomization/causality引用本文复制引用
刘佳进,缪长宏,徐健康,余伟杰,陈继鑫,唐好知,刘爱峰..肠道菌群与色素沉着绒毛结节性滑膜炎之间的因果关系:基于孟德尔随机化分析[J].南方医科大学学报,2024,44(7):1397-1406,10.基金项目
国家自然科学基金(81873316) （81873316）
天津市科技计划项目(23KPXMRC00170) （23KPXMRC00170）
天津市卫健委津门医学英才项目(TJSJMYXYC-D2-028) Supported by National Natural Science Foundation of China(81873316). （TJSJMYXYC-D2-028）
