分析化学2024，Vol.52Issue(7)：955-963,9.DOI:10.19756/j.issn.0253-3820.241220
可注射荧光硫化铋/金纳米簇水凝胶用于肿瘤术后光热治疗和促进伤口愈合性能分析
Injectable Fluorescent Bi2S3/Au Nanoclusters Hydrogel for Postoperative Photothermal Therapy of Tumor and Promoting Wound Healing
摘要
Abstract
Herein,a new multifunctional hydrogel wound dressing was fabricated for the first time based on the crosslinking between catechol-modified chitosan(CHI-C)and bismuth sulfide-gold nanocluster nanoparticles(Bi2S3-Au NCs NPs)by simple stirring at room temperature within 1 min.Benefit from the good biocompatibility of CHI-C and excellent photothermal abilily of Bi2S3-Au NCs NPs,it could achieve postoperative photothermal therapy of tumor residual tissue and wound healing.More importantly,the as-prepared hydrogel with fluorescent property could accurately monitor the postoperative wound filling in real-time,which was critical to wound healing,especially for irregular wounds.The smart hydrogel was expected to provide a new perspective for preventing and reducing cancer recurrence and wound infection after surgery.关键词
多功能水凝胶/硫化铋-金纳米簇/光热治疗/荧光/术后伤口Key words
Multifunctional hydrogel/Bismuth sulfide-gold nanocluster nanoparticles/Photothermal therapy/Fluorescence/Postoperative wounds引用本文复制引用
李卓,杨绍贤,刘蕊,杨正林,曹玉玉,孙红梅..可注射荧光硫化铋/金纳米簇水凝胶用于肿瘤术后光热治疗和促进伤口愈合性能分析[J].分析化学,2024,52(7):955-963,9.基金项目
湖北工业大学国家"111"细胞调控与分子药学中心合作资助项目(No.XBTK-2022007)和湖北省教育厅科研计划项目(No.B2017047)资助. Supported by the Collaborative Grant-in-Aid of the HBUT National"111"Center for Cellular Regulation and Molecular Pharmaceutics(No.XBTK-2022007)and the Scientific Research Program Project of Hubei Provincial Department of Education(No.B2017047). （No.XBTK-2022007）
