分子影像学杂志2024，Vol.47Issue(7)：684-688,5.
单侧颈内动脉闭塞患者脑灌注与症状、闭塞时期及闭塞位置的关系
Relationship between symptoms,occlusion period,and site with cerebral perfusion in patients with internal carotid artery occlusion
摘要
Abstract
Objective To assess the relationship between symptoms and cerebral perfusion in patients with unilateral internal carotid artery occlusion(ICAO),and the influence of the occlusion period and location on cerebral perfusion.Methods Sixteen patients with ICAO who met the inclusion and exclusion criteria were enrolled in the Department of Neurology of the Second Affiliated Hospital of Xi'an Jiaotong University from September 2021 to March 2023.Regional cerebral blood flow(CBF)was measured by Dr Brain's software ASL module.Differences in regional CBF in global,middle cerebral artery(MCA)territory,anterior cerebral artery territory,Alberta Stroke Programme Early Computed Tomography Score(ASPECTS)regions(include caudate nucleus,lentiform nucleus,insula ribbon,internal capsule and M1-M6)and brain lobes(include frontal,parietal,temporal,insular lobe)of different subgroups(symptomatic and asymptomatic,acute and chronic,initial and intracranial ICAO)at PLD 1.5 s and PLD 2.5 s were evaluated.Results The CBF of symptomatic and asymptomatic,acute and chronic,initial and intracranial ICAO patients found no differences in the global and contralateral hemisphere at PLD 1.5 s and PLD 2.5 s(P＞0.05).The CBF of initial and intracranial ICAO patients found no differences in the ipsilateral hemisphere at PLD 1.5 s and PLD 2.5 s(P＞0.05).In the occluded hemisphere,the CBF of symptomatic ICAO was significantly lower than that of asymptomatic at PLD 1.5 s in M5,the CBF of symptomatic was significantly higher than that of asymptomatic at PLD 1.5 s in internal capsule(P＜0.05).The CBF of symptomatic and asymptomatic ICAO found no differences in the ipsilateral hemisphere at PLD 2.5 s(P＞0.05).In the occluded hemisphere,the CBF of acute ICAO was significantly lower than that of chronic at PLD 1.5 s in middle cerebral artery territory,M1,M5,frontal lobe;the CBF of acute ICAO was significantly lower than that of chronic at PLD 2.5 s in middle cerebral artery territory,M1,M5,M6,frontal lobe(P＜0.05).Conclusion Acute ICAO has further perfusion impairment than chronic ICAO in the middle cerebral artery territory and partly ASPECTS cortical areas of the occluded side.Symptomatic ICAO was associated with further perfusion impairment in partly ASPECT area of the occluded side.There was no significant difference in cerebral perfusion at different locations of internal carotid artery occlusion.关键词
动脉自旋标记/颈内动脉闭塞/脑血流量/缺血性卒中/血流动力学Key words
arterial spin labeling/internal carotid artery occlusion/cerebral blood flow/ischemic stroke/hemodynamic引用本文复制引用
张桂荣,张妍妍,梁文斌,丁墩..单侧颈内动脉闭塞患者脑灌注与症状、闭塞时期及闭塞位置的关系[J].分子影像学杂志,2024,47(7):684-688,5.基金项目
陕西省重点研发计划-一般项目-社会发展领域(S2023-YF-YBSF-0273) （S2023-YF-YBSF-0273）
陕西省自然科学基础研究计划一般项目(青年项目)(2022JQ-900) （青年项目）
