分子影像学杂志2024，Vol.47Issue(7)：695-701,7.
磁敏感成像联合经颅黑质超声对帕金森病具有良好诊断价值
Magnetic susceptibility imaging combined with transcranial sonography is good in predicting Parkinson's disease
摘要
Abstract
Objective To explore the diagnostic value of susceptibility-weighted imaging(SWI)combining transcranial sonography(TCS)in Parkinson's disease(PD).Methods Forty-two PD patients treated at the First People's Hospital of Foshan from January 2021 to December 2023 were selected as the PD group,while 43 healthy volunteers served as the control group.All subjects underwent SWI and TCS examinations to observe the disappearance of the"swallow tail sign"in the midbrain substantia nigra.Differences in the hyperechoic area of the substantia nigra(SN),midbrain area,and the S/M values were analyzed between the groups.Statistically significant indicators were subjected to multivariate logistic regression analysis to identify independent predictors of PD and construct a predictive model,which was visualized using a nomogram.The model's discriminative ability,calibration,and clinical utility were evaluated using ROC curves,calibration curves,and decision curve analysis,respectively.Results There were significant differences in the hyperechoic area of the SN(P＜0.001)and the S/M ratio(P＜0.001)between the PD group and the control group.The AUC for SWI and TCS separately in distinguishing PD from control group were 0.80(95%CI:0.716-0.886)and 0.857(95%CI:0.774-0.940),respectively.Multivariate Logistic regression analysis showed that the hyperechoic area of SN and the swallow tail sign as independent risk factors for predicting PD.The predictive model constructed using these factors had an AUC value of 0.94(95%CI:0.896-0.984).The calibration curve demonstrated good agreement between predicted and actual probabilities,and decision curve analysis showed that the predictive model provided a higher net benefit than individual indicators.Conclusion The predictive model combining SWI and TCS quantitative indicators demonstrates good predictive capability for PD risk,surpassing any single model and showing promising clinical utility.关键词
磁敏感成像/经颅黑质超声/列线图/帕金森病Key words
susceptibility weighted imaging/transcranial sonography/Nomogram/Parkinson's disease引用本文复制引用
成东亮,段振鹏,吴耀忠,王航,马锦成,黄淑英,文戈,丁楠,赵海..磁敏感成像联合经颅黑质超声对帕金森病具有良好诊断价值[J].分子影像学杂志,2024,47(7):695-701,7.基金项目
佛山市卫生健康局医学科研项目(20220809A010293) （20220809A010293）
佛山市"十四五"高水平医学重点专科项目(FSGSP145036) （FSGSP145036）
