摘要
Abstract
Objective:To study the effect of compound azinomide in the treatment of severe erosive gastritis complicated with dyspepsia and its effect on the recovery of gastric mucosa function.Methods:Ninety-seven patients admitted to Hebi People's Hospital from September 2021 to May 2023 were randomly divided into the conventional group(n=48)and the study group(n=49).The conventional group received conventional treatment,and the study group combined with compound azino-mide.Both groups received continuous treatment for 4 weeks.Data were collected.The pain degree,gastrointestinal function improvement time,gastrointestinal hormone level,gastric mucosal function and adverse reactions were compared between the two groups.Results:After treatment,the time of abdominal pain and distension elimination,VAS score,gastrointestinal singing restoring time and anal exhaust restoring time in the study group were(4.48±1.37)d,(2.08±0.68)scores,(3.91±0.89)d and(4.32±1.10)d,respectively,which were lower than these in the conventional group(5.29±1.50)d,(2.95±0.74)scores,(4.58±1.25)d,(5.02±1.35)d(P<0.01).After treatment,the levels of pepsinogen(PGⅡ,PGⅠ),gastrin-17(GAS-17)and 5-hydroxytryptamine(5-HT)in the study group were(17.02±3.51)μg/L,(134.25±11.60)μg/L,(7.62±2.38)pmol/L and(191.20±12.58)mg/L,respectively,which were higher than these in the conventional group(13.92±3.25)μg/L,(120.58±9.84)μg/L,(5.84±2.12)pmol/L,(178.69±14.60)mg/L(P<0.001).After treatment,the levels of basic fi-broblast growth factor(bFGF),antigen Ki-67 and epidermal growth factor(EGF)in the study group were(492.66±35.26)×103,97.69±8.46 and(349.84±22.65)×103,respectively,which were lower than(520.12±38.62)×103,103.54±9.85,(368.25±25.98)×103 in the conventional group(P<0.01).Conclusions:Compound azinomide treatment can effectively re-duce the pain degree of patients with severe vesicant gastritis complicated with dyspepsia,regulate the level of gastrointestinal hormone,protect gastric mucosa function,promote the recovery of gastrointestinal function,and have high safety.关键词
胃炎,糜烂性/复方阿嗪米特/消化不良/胃肠功能Key words
Erosive gastritis/Compound azinamide/Indigestion/Gastrointestinal function分类
医药卫生
