中国妇幼健康研究2024，Vol.35Issue(7)：79-84,6.DOI:10.3969/j.issn.1673-5293.2024.07.013
sFlt-1/PlGF比值联合D-二聚体评估子痫前期妊娠结局的临床价值
The clinical value of sFlt-1/PlGF ratio combined with D-D in assessing the pregnancy outcomes of preeclampsia
摘要
Abstract
Objective To explore the clinical value of the soluble fms-like tyrosine kinase-1(sFlt-1)/placental growth factor(P1GF)ratio combined with D-dimer(D-D)in assessing the pregnancy outcomes of preeclampsia(PE).Methods Retrospectively,102 cases of PE patients admitted from December 2021 to January 2023 were selected as the PE group,while 60 normal pregnant women undergoing prenatal examinations in our hospital during the same period were selected as the control group.The serum sFlt-1,PlGF,sFlt-1/PlGF ratio and D-D at 28 to 32 weeks were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of sFlt-1/PlGF ratio combined with D-D for pregnancy outcome.Results Serum levels of sFlt-1,sFlt-1/PlGF ratio and D-D in PE group were higher than those in control group,while P1GF level in the PE group was lower than those in control group(t=10.855,20.310,17.002,and 15.365,P＜0.05).Logistic analysis showed that high body mass index(BMI),gestational diabetes mellitus or kidney disease,history of PE,sFlt-1/PlGF ratio and D-D were independent risk factors for PE in pregnant women,with OR values and 95% CI of 18.171(6.493-50.849),4.259(1.096-16.547),11.367(1.226-105.391),7.939(2.514-25.068),and 1.567(1.330-1.845),respectively,P＜0.05.Serum levels of sFlt-1,sFlt-1/PlGF ratio and D-D in adverse pregnancy outcome group were higher than those in good pregnancy outcome group,while P1GF level was lower than those in non-adverse pregnancy outcome group,while P1GF levels in adverse pregnancy outcome group were lower than in the non-adverse pregnancy outcome group(t=4.759,5.646,5.331,and 3.135,P＜0.05).ROC curves analysis showed that sFlt-1/PlGF ratio combined with D-D had an area under the curve(AUC)of 0.843 for predicting pregnancy outcomes,with sensitivity and specificity of 79.41% and 75.00% ,respectively.Conclusion PE patients have elevated serum sFlt-1/PlGF ratio and D-D levels,both of which can be used to assess the pregnancy outcome of PE.关键词
子痫前期/妊娠结局/可溶性fms样酪氨酸激酶1/胎盘生长因子/D-二聚体Key words
preeclampsia/pregnancy outcomes/soluble fms-like tyrosine kinase-1/placental growth factor/D-dimer分类
医药卫生引用本文复制引用
刘陈,侯雪晶,郭丽魁,魏敬艳,裴梦然..sFlt-1/PlGF比值联合D-二聚体评估子痫前期妊娠结局的临床价值[J].中国妇幼健康研究,2024,35(7):79-84,6.基金项目
秦皇岛市科学技术研究与发展计划项目(201902A048) （201902A048）
