国际医学放射学杂志2024，Vol.47Issue(4)：407-411,5.DOI:10.19300/j.2024.L21351
7 T MRI对帕金森病扩大的血管周围间隙与运动症状的相关性研究
Study on the correlation between enlarged perivascular space and motor symptoms in Parkinson's disease using 7 T MRI
摘要
Abstract
Objective Utilizing 7 T MRI to study the correlation between enlarged perivascular spaces(EPVS)and motor symptoms in Parkinson's disease(PD)patients,and to explore the diagnosing value of EPVS measured with 7 T MRI.Methods Fourteen patients clinically diagnosed with PD(PD group)were prospectively included in the study.Their motor symptoms were evaluated using the Hoehn-Yahr(H-Y)staging and the unified Parkinson's disease rating scale(UPDRS).Additionally,17 healthy controls(HC group)were included.Both groups underwent 7 T MRI examinations,and the EPVS in the centrum semiovale and basal ganglia were analyzed on T2WI and T2-fluid attenuated inversion recovery(FLAIR)images,with EPVS counted and scored.An independent samples t-test was used to compare the differences in the number and scores of EPVS in the centrum semiovale and basal ganglia between the two groups.Pearson correlation analysis was employed to assess the correlation between the scores and number of EPVS in the centrum semiovale and basal ganglia and the motor symptom scores in PD patients.Results The PD group had a higher number of EPVS in the basal ganglia region and higher EPVS scores in the centrum semiovale than the HC group(both P＜0.05).There was a positive correlation between the H-Y stage and the number of EPVS in the basal ganglia region in PD patients(r=0.242,P＜0.001).No correlation was found between other motor symptom scores and EPVS numbers or scores(all P＞0.05).Conclusions EPVS were more numerous in PD patients than in healthy controls on 7 T MRI.The motor symptoms positively correlated with the number of EPVS in the basal ganglia in PD patients,suggesting that EPVS measured on 7 T MRI could potentially serve as an imaging biomarker for PD.关键词
帕金森病/磁共振成像/超高场强/血管周围间隙/运动症状Key words
Parkinson's disease/Magnetic resonance imaging/Ultra high filed/Perivascular space/Motor symptoms分类
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王心宇,陆皓璇,熊永琴,章露华,王晓玉,黄佳宇,李岩,娄昕..7 T MRI对帕金森病扩大的血管周围间隙与运动症状的相关性研究[J].国际医学放射学杂志,2024,47(4):407-411,5.基金项目
国家自然科学基金项目(81825012,82327803,82151309,82271952,82302146) （81825012,82327803,82151309,82271952,82302146）
