补肾开窍方通过调控ERK1/2和铁死亡治疗糖尿病合并缺血性卒中机制研究OACSTPCD
Mechanism of Bushen Kaiqiao Formula in Treating Diabetes Mellitus Complicated with Ischemic Stroke by Regulating ERK1/2 and Ferroptosis
目的:采用网络药理学和分子对接、动物实验探讨并验证补肾开窍方治疗糖尿病合并缺血性卒中的分子作用机制.方法:雄性SD大鼠48 只,随机分为假手术组12 只和造模组36 只,造模组大鼠第1 天和第4 天分别腹腔注射1%链脲佐菌素(strepto-zotocin,STZ,50 mg·kg-1)各1 次,第14 天采用大脑中动脉栓塞(middle cerebral artery occlusion,MCAO)法建立糖尿病合并缺血性卒中模型大鼠.将造模组大…查看全部>>
Objective:To explore and verify the molecular mechanism of Bushen Kaiqiao Formula in the treatment of diabetes mellitus combined with ischemic stroke based on network pharmacology,molecular docking and animal experiments.Methods:48 male SD rats were randomly divided into a sham operation group of 12 and a modeling group of 36,and the modeling group rats were injected with 1%streptozotocin(STZ,50 mg·kg-1)intraperitoneally once on days 1 and 4,respectively.On …查看全部>>
刘孟涵;傅晨;刘云婷;巩俐;杨小蕊;刘雪梅
北京中医药大学东方医院,北京 100078北京中医药大学东方医院,北京 100078北京中医药大学东方医院,北京 100078北京中医药大学东方医院,北京 100078北京中医药大学东方医院,北京 100078北京中医药大学东方医院,北京 100078
中医学
补肾开窍方缺血性卒中糖尿病ERK1/2铁死亡网络药理学分子对接
Bushen Kaiqiao Formulaischemic strokediabetes mellitusERK1/2ferroptosisnetwork pharmacologymolecular docking
《中医学报》 2024 (8)
1591-1600,10
国家自然科学基金项目(81973788)
评论