中医药防治胃黏膜"炎-癌转化"研究进展OACSTPCD

The occurrence of gastric cancer goes through the process of"chronic non-atrophic gastritis-chronic atrophic gastritis-in-testinal metaplasia-dysplasia-gastric cancer",namely,the"inflammation-to-cancer transition"in brief.From this prospect,re-searchers have been committed to the study on the prevention and treatment of"inflammation-to-cancer transition"of gastric muco-sa.At present,western medicine is focused on symptomatic treatment such as eradication of Helicobacter pylori,inhibition of acid and protection of gastric mucosa,which cannot fundamentally prevent the occurrence and development of gastric cancer.Traditional Chinese medicine has less adverse reactions and toxic side effects in the treatment of the disease,while the related mechanism is not completely clear.Metabolomics,as an emerging omics technology,matches the multi-target and multi-pathway characteristics of TCM.By using metabolomics to explore the mechanism of TCM in prevention and treatment of gastric mucosal"inflammation-cancer transformation",it is found that the main mechanism of TCM in the prevention and treatment of"inflammation-to-cancer transition"of gastric mucosa is closely related to the regulation of energy metabolism,amino acid metabolism and lipid metabolism,which provides new methods and theoretical perspective for interpreting the complex mechanism and scientific connotation of TCM on a micro level.