铜死亡及其抗肿瘤机制OACSTPCD

Copper(Cu)is a cofactor involved in a variety of biological metabolic pathways in the body and plays an important role in physiological processes such as cellular respiration and neurotransmitter transmission.The key to cuproptosis is the accumulation of Cu ions combined with the fatty acylated components of the tricarboxylic acid cycle,leading to the aggregation of fatty acylated proteins and the loss of iron-sulfur cluster proteins,thus resulting in cellular proteotoxic stress.cuproptosis is closely related to the formation and development of tumor diseases.At present,the etiology and progression mechanism of tumors are mainly based on autophagy,apoptosis,pyroptosis,Ferroptosis and other aspects.In addition,the epithelial-mesenchymal transition,extracellular matrix remodeling and vascu-lar endothelial growth factor expression in tumor microenvironment are studied.The experimental study of effect on cuproptosis of TCM intervention is insufficient,so there is still a lot of space for exploring cuproptosis and its anti-tumor mechanism with traditional Chi-nese medicine.