中医学报2024，Vol.39Issue(8)：1679-1686,8.DOI:10.16368/j.issn.1674-8999.2024.08.276
铜死亡及其抗肿瘤机制
Cuproptosis and Its Anti-tumor Mechanism
摘要
Abstract
Copper(Cu)is a cofactor involved in a variety of biological metabolic pathways in the body and plays an important role in physiological processes such as cellular respiration and neurotransmitter transmission.The key to cuproptosis is the accumulation of Cu ions combined with the fatty acylated components of the tricarboxylic acid cycle,leading to the aggregation of fatty acylated proteins and the loss of iron-sulfur cluster proteins,thus resulting in cellular proteotoxic stress.cuproptosis is closely related to the formation and development of tumor diseases.At present,the etiology and progression mechanism of tumors are mainly based on autophagy,apoptosis,pyroptosis,Ferroptosis and other aspects.In addition,the epithelial-mesenchymal transition,extracellular matrix remodeling and vascu-lar endothelial growth factor expression in tumor microenvironment are studied.The experimental study of effect on cuproptosis of TCM intervention is insufficient,so there is still a lot of space for exploring cuproptosis and its anti-tumor mechanism with traditional Chi-nese medicine.关键词
铜死亡/抗肿瘤/细胞凋亡/细胞自噬/泛素-蛋白酶体系统/免疫毒性Key words
cuproptosis/anti-tumor/cell apoptosis/cell autophagy/ubiquitin proteasome system/immunotoxicity分类
医药卫生引用本文复制引用
梁欣奕,马佳乐,赵双梅,杨岩,李慧臻..铜死亡及其抗肿瘤机制[J].中医学报,2024,39(8):1679-1686,8.基金项目
国家自然科学基金面上项目(81573889) （81573889）
天津市卫生健康委员会中医药重点领域科研项目(202007) （202007）
