中药调控不同信号通路防治阿尔茨海默病的研究进展OACSTPCD

Traditional Chinese medicine can improve cognitive impairment in Alzheimer's disease(AD)by regulating different signaling pathways,such as phosphoinositide-3 kinase/protein kinase B(PI3K/Akt),brain-derived neurotrophic factor/tyrosine kinase recep-tors(BDNF/TrkB),nuclear factor E2-related factor 2/heme oxygenase-1(Nrf2/HO-1),mitogen-activated protein kinase(MAPK),Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway,etc.These targets and levels of each pathway acting on AD are different,mainly involved in promoting cell proliferation and differentiation,inhibiting cell apoptosis,reducing oxidative stress injury,regulating inflammatory response,and promoting cell autophagy.The existing studies on the AD treatment with AD are mostly focused on TCM monomers or single signaling pathway.It needs further studies on multi-target effects of TCM com-pound components as well as the expression of upstream and downstream protein receptors between each pathway.The optimal concen-tration of TCM has not been unified.In addition,the experiment research are mainly focused on the treatment of AD animal models or related cells with TCM,while pathway blockers or related gene knockout methods are rarely used to verify its regulatory mechanism in turn.There is an urgent need for further high quality and large sample clinical trials to clarify the relationship between different path-ways regulated by TCM in the treatment of AD,to expand the research ideas on the mechanism,to provide theoretical basis for the clini-cal application of TCM in prevention and treatment of AD and other neurodegenerative diseases.