中医药调控TLR4信号通路防治糖尿病肾病研究进展OACSTPCD

The TLR4 signaling pathway is closely related to the pathogenesis of diabetic kidney disease(DKD).TCM has achieved good clinical efficacy in the prevention and treatment of DKD with some advantages such as multiple targets,effects,and components.TCM can inhibit the kidney inflammation,reducing oxidative stress,improve renal fibrosis and decrease cell apoptosis by regulating TLR4 sig-naling pathway,which has become an important target for the prevention and treatment of DKD with TCM.However,at present,the re-search related to the prevention and treatment of DKD by traditional Chinese medicine is still mainly based on basic experiments,and there is a lack of high-quality large-sample clinical trial verification.The existing research are mostly focused on single signaling pathway,and the molecular mechanism has not been clarified.From this prospect,it is necessary to further explore the connection and intersection of multiple pathways such as TLR4 to clarify mechanism of the multi-target and multi-pathway,as well as the active com-ponents of TCM and their mechanism by using network pharmacology and multi-omics joint analysis technology,so as to provide new i-deas for the prevention and treatment of DKD with TCM.