中医学报2024，Vol.39Issue(8)：1695-1700,6.DOI:10.16368/j.issn.1674-8999.2024.08.278
中医药调控TLR4信号通路防治糖尿病肾病研究进展
Research Progress of TCM in Prevention and Treatment of Diabetic Nephropathy by Regulating TLR4 Signaling Pathway
摘要
Abstract
The TLR4 signaling pathway is closely related to the pathogenesis of diabetic kidney disease(DKD).TCM has achieved good clinical efficacy in the prevention and treatment of DKD with some advantages such as multiple targets,effects,and components.TCM can inhibit the kidney inflammation,reducing oxidative stress,improve renal fibrosis and decrease cell apoptosis by regulating TLR4 sig-naling pathway,which has become an important target for the prevention and treatment of DKD with TCM.However,at present,the re-search related to the prevention and treatment of DKD by traditional Chinese medicine is still mainly based on basic experiments,and there is a lack of high-quality large-sample clinical trial verification.The existing research are mostly focused on single signaling pathway,and the molecular mechanism has not been clarified.From this prospect,it is necessary to further explore the connection and intersection of multiple pathways such as TLR4 to clarify mechanism of the multi-target and multi-pathway,as well as the active com-ponents of TCM and their mechanism by using network pharmacology and multi-omics joint analysis technology,so as to provide new i-deas for the prevention and treatment of DKD with TCM.关键词
糖尿病肾病/TLR4信号通路/中医药Key words
diabetic kidney disease/TLR4 signaling pathway/traditional Chinese medicine分类
医药卫生引用本文复制引用
高亚丽,段玉红,王慧霞,董佩..中医药调控TLR4信号通路防治糖尿病肾病研究进展[J].中医学报,2024,39(8):1695-1700,6.基金项目
陕西省中医药管理局科研计划项目(2019-GJ-QT002) （2019-GJ-QT002）
陕西省自然科学基础研究计划项目(2022JM-494) （2022JM-494）
