针刺治疗肌萎缩侧索硬化症研究进展OACSTPCD

The related studies of acupuncture in treatment of amyotrophic lateral sclerosis(ALS)have gradually increased in recent years,which can effectively delay the course of ALS and reduce the occurrence of adverse reactions by inhibiting glutamate excitotoxici-ty,reducing oxidative stress disorder as well as inhibiting neuroinflammatory response and cell apoptosis to improve the life quality of patients.There are various acupuncture therapies,among which the combination of acupuncture and medication as well as electro-acu-puncture are the most common clinical applications,which can effectively improve the dyskinesia of patients.However,there are still some shortcomings in the clinical application and experimental research of acupuncture for ALS,such as small sample size in clinical re-search,single observation index,lack of rigor in experimental design,lack of standardization and unity in TCM syndrome differentiation and diagnosis,lack of systematic standards for specific operation,as well as the unclear mechanism.In the future,it is proposed to fur-ther standardize the TCM syndrome differentiation,enlarge the sample size of clinical trials,combine experiment research with clinical application as well,to improve the clinical efficacy of acupuncture in the treatment of ALS.