半夏厚朴汤治疗痰湿阻肺型慢性阻塞性肺疾病临床研究OA
Clinical Study on Pinellia and Officinal Magnolia Bark Decoction in Treating Chronic Obstructive Pulmonary Disease with Syndrome of Phlegm-Dampness Obstructing the Lung
目的:观察半夏厚朴汤治疗痰湿阻肺型慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的临床疗效.方法:将73 例痰湿阻肺型COPD患者按照抽签法分为对照组35 例和观察组38 例.对照组给予常规西医治疗,观察组在对照组治疗的基础上给予半夏厚朴汤治疗.比较两组患者治疗前后自我评估测试(chronic obstructive pulmonary disease self assess-ment test questionnaire,CAT)评分、血清指标[转化生长因子-β(transforming growth factor-β,TGF-β)、核转录因子NF-κB(nuclear transcription factor-κB,NF-κB)]、胃肠功能(胃动素、胃泌素)、呼吸参数(呼吸频率、分钟通气量、平均气道压)及气道重塑影像学参数(气道壁厚度、气道壁面积)变化情况.结果:两组患者治疗后CAT评分、TGF-β、NF-κB水平低于本组治疗前,且治疗后观察组低于对照组(P<0.05).两组患者治疗后胃动素、胃泌素水平高于对照组,且治疗后观察组高于对照组(P<0.05).两组患者治疗后呼吸频率、平均气道压低于本组治疗前,分钟通气量高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05).两组气道壁厚度、气道壁面积低于本组治疗前,且治疗后观察组低于对照组(P<0.05).结论:半夏厚朴汤治疗痰湿阻肺型COPD,可改善患者的临床症状和气道重塑,提高肺功能指标,抑制炎性因子水平.
Objective:To observe the clinical efficacy of Pinellia and Officinal Magnolia Bark Decoction on chronic obstructive pulmonary disease(COPD)with syndrome of phlegm-dampness obstructing the lung.Methods:A total of 73 patients with COPD with syndrome of phlegm-dampness obstructing the lung were divided into the control group with 35 cases and the observation group with 38 cases accord-ing to the random number table method.The control group was given conventional Western medicine treatment,while the observation group was added Pinellia and Officinal Magnolia Bark Decoction on the basis of the control group.The changes in chronic obstructive pulmonary disease self-assessment test questionnaire(CAT)scores,serum indicators[including transforming growth factor-β(TGF-β),nuclear transcription factor-κB(NF-κB)],gastrointestinal function(including motilin,gastrin),respiratory parameters(including respiratory rate,minute ventilation,average airway pressure),and airway remodeling imaging parameters(including airway wall thick-ness,airway wall area)were compared between the two groups.Results:After treatment,the CAT scores,TGF-β,and NF-κB levels of the two groups were lower than those before treatment,and the observation group's above indexes were lower than those of the control group(P<0.05);the levels of motilin and gastrin in the two groups were higher than those in the control group,and the observation group's above levels were higher than those of the control group(P<0.05);the respiratory rate and average airway pressure of the two groups were lower than those before treatment,and the minute ventilation volume was higher than that before treatment.The differences between the two groups were statistically significant(P<0.05);the thickness and area of the airway wall in both groups were lower than those before treatment,and the observation group's above indexes were lower than those of the control group(P<0.05).Conclu-sion:Pinellia and Officinal Magnolia Bark Decoction can improve the clinical symptoms and airway remodeling of COPD patients with syndrome of phlegm-dampness obstructing the lung,enhance lung function indicators,and inhibit the level of inflammatory factors.
杨西霞;朱慧
济南市中西医结合医院,山东 济南 271100
中医学
慢性阻塞性肺疾病半夏厚朴汤痰湿阻肺证《金匮要略》张仲景
chronic obstructive pulmonary disease(COPD)Pinellia and Officinal Magnolia Bark Decoctionsyndrome of phlegm-damp-ness obstructing the lungSynopsis of the Golden ChamberZhang Zhongjing
《河南中医》 2024 (008)
1154-1158 / 5
山东省自然科学基金项目(KH202109021354)
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