黄芪桂枝五物汤加味治疗周围神经病变临床研究OA
Clinical Study on Supplemented Astragalus and Cinnamon Twig Five Substances Decoction in the Treatment of Peripheral Neuropathy
目的:观察黄芪桂枝五物汤加味治疗周围神经病变的临床疗效.方法:选取驻马店市中医院 2021 年 6 月至 2023 年 11月治疗的周围神经病变患者106 例,按照随机数字表法分为对照组和观察组,每组各53 例.对照组给予常规西药治疗,观察组在对照组治疗的基础上加用黄芪桂枝五物汤加味治疗.比较两组患者治疗前后中医证候积分、神经传导速度[感觉神经传导速度(sensory nerve conduction velocity,SCV)、运动神经传导速度(motor nerve conduction velocity,MCV)]、炎性因子[白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]、氧化应激指标[丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)]变化情况,比较两组患者不良反应发生情况.结果:两组患者治疗后肢体麻木、疼痛以及乏力等中医证候积分低于本组治疗前,且治疗后观察组低于对照组(P<0.05).两组患者治疗后MCV、SCV高于本组治疗前,且治疗后观察组高于对照组(P<0.05).两组患者治疗后IL-6、CRP、TNF-α水平低于本组治疗前,且治疗后观察组低于对照组(P<0.05).两组患者治疗后MDA低于本组治疗前,SOD高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05).观察组不良反应发生率低于对照组(P<0.05).结论:黄芪桂枝五物汤加味治疗周围神经病变,可改善患者的临床症状、降低炎性因子水平,其作用机制可能与改善应激反应水平有关.
Objective:To observe the clinical efficacy of Supplemented Astragalus and Cinnamon Twig Five Substances Decoction on pe-ripheral neuropathy.Methods:A total of 106 patients with peripheral neuropathy treated at Zhumadian Chinese Medicine Hospital from June 2021 to November 2023 were selected and randomly divided into the control group and the observation group,with 53 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with Supplemented Astragalus and Cinnamon Twig Five Substances Decoction on the basis of the control group.The changes in TCM syndrome scores,nerve conduction velocities[including sensory nerve conduction velocity(SCV),and motor nerve conduction velocity(MCV)],inflammatory factors[including interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],and oxidative stress indicators[including malondialdehyde(MDA),superoxide dismutase(SOD)]before and after treatment between two groups were compared.The occurrence of adverse reactions of the two groups were also compared.Results:After treatment,the TCM syndrome scores,such as limb numbness,pain,and fatigue in the two groups were lower than those before treatment,and the TCM syndrome scores of the observation group were lower than those of the control group(P<0.05);The MCV and SCV of the two groups were higher than those before treat-ment,and the MCV and SCV of the observation group were higher than those of the control group(P<0.05);The levels of IL-6,CRP,and TNF-α in the two groups were lower than those before treatment,and the above indicators in the observation group were lower than those in the control group(P<0.05);The MDA levels of the two groups were lower than those before treatment,while the SOD level was higher than that before treatment.The differences between the two groups were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Supplemented Astragalus and Cinnamon Twig Five Substances Decoction can improve clinical symptoms and reduce inflammatory factor levels in patients with pe-ripheral neuropathy,and its mechanism of action may be related to improving stress response levels.
李子斌;李可法;梁建军
驻马店市中医院,河南 驻马店 463000
中医学
周围神经病变黄芪桂枝五物汤《金匮要略》张仲景
peripheral neuropathyAstragalus and Cinnamon Twig Five Substances DecoctionSynopsis of the Golden ChamberZhang Zhongjing
《河南中医》 2024 (008)
1159-1163 / 5
河南省中医药科学研究专项课题项目(2022ZY02121)
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