河南中医2024，Vol.44Issue(8)：1159-1163,5.DOI:10.16367/j.issn.1003-5028.2024.08.0213
黄芪桂枝五物汤加味治疗周围神经病变临床研究
Clinical Study on Supplemented Astragalus and Cinnamon Twig Five Substances Decoction in the Treatment of Peripheral Neuropathy
摘要
Abstract
Objective:To observe the clinical efficacy of Supplemented Astragalus and Cinnamon Twig Five Substances Decoction on pe-ripheral neuropathy.Methods:A total of 106 patients with peripheral neuropathy treated at Zhumadian Chinese Medicine Hospital from June 2021 to November 2023 were selected and randomly divided into the control group and the observation group,with 53 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with Supplemented Astragalus and Cinnamon Twig Five Substances Decoction on the basis of the control group.The changes in TCM syndrome scores,nerve conduction velocities[including sensory nerve conduction velocity(SCV),and motor nerve conduction velocity(MCV)],inflammatory factors[including interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],and oxidative stress indicators[including malondialdehyde(MDA),superoxide dismutase(SOD)]before and after treatment between two groups were compared.The occurrence of adverse reactions of the two groups were also compared.Results:After treatment,the TCM syndrome scores,such as limb numbness,pain,and fatigue in the two groups were lower than those before treatment,and the TCM syndrome scores of the observation group were lower than those of the control group(P<0.05);The MCV and SCV of the two groups were higher than those before treat-ment,and the MCV and SCV of the observation group were higher than those of the control group(P<0.05);The levels of IL-6,CRP,and TNF-α in the two groups were lower than those before treatment,and the above indicators in the observation group were lower than those in the control group(P<0.05);The MDA levels of the two groups were lower than those before treatment,while the SOD level was higher than that before treatment.The differences between the two groups were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Supplemented Astragalus and Cinnamon Twig Five Substances Decoction can improve clinical symptoms and reduce inflammatory factor levels in patients with pe-ripheral neuropathy,and its mechanism of action may be related to improving stress response levels.关键词
周围神经病变/黄芪桂枝五物汤/《金匮要略》/张仲景Key words
peripheral neuropathy/Astragalus and Cinnamon Twig Five Substances Decoction/Synopsis of the Golden Chamber/Zhang Zhongjing分类
医药卫生引用本文复制引用
李子斌,李可法,梁建军..黄芪桂枝五物汤加味治疗周围神经病变临床研究[J].河南中医,2024,44(8):1159-1163,5.基金项目
河南省中医药科学研究专项课题项目(2022ZY02121) （2022ZY02121）
