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加味麻杏石甘汤治疗小儿急性支气管炎临床研究OA

Clinical Study on the Treatment of Acute Bronchitis in Children with Supplemented Ephedra and Apricot Kernel and Gypsum and Licorice Decoction

中文摘要英文摘要

目的:观察加味麻杏石甘汤治疗小儿急性支气管炎风热犯肺证的临床疗效.方法:将82 例郑州市中医院2021 年7 月至2023 年7 月收治的急性支气管炎患儿按照随机数字表法分为对照组和观察组,每组各 41 例.对照组采用常规西药治疗,观察组在对照组治疗的基础上给予加味麻杏石甘汤.比较两组患儿的临床疗效、症状改善情况及治疗前后中医证候积分、T淋巴亚群(CD3+、CD4+、CD4+/CD8+)、炎性因子水平[C反应蛋白(C reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]变化情况.结果:观察组有效率为 95.12%,高于对照组的78.05%,差异具有统计学意义(P<0.05).两组患儿治疗后中医证候积分、TNF-α、CRP、IL-6 低于本组治疗前,且治疗后观察组低于对照组(P<0.05).两组患儿治疗后CD3+、CD4+、CD4+/CD8+高于本组治疗前,且治疗后观察组高于对照组(P<0.05).观察组体温恢复正常时间及咳嗽、咯痰、肺啰音消失时间短于对照组(P<0.05).结论:加味麻杏石甘汤联合常规西药治疗小儿急性支气管炎,可改善患儿的临床症状,促进咳嗽、咳痰、肺啰音等症状消失及体温恢复正常,增强机体免疫功能.

Objective:To observe the clinical efficacy of Supplemented Ephedra and Apricot Kernel and Gypsum and Licorice Decoction on acute bronchitis in children.Methods:A total of 82 children with acute bronchitis admitted to our hospital from July 2021 to July 2023 were divided into two groups using the random number table method,with 41 cases in each group.The control group received con-ventional Western medicine treatment,while the observation group received Supplemented Ephedra and Apricot Kernel and Gypsum and Licorice Decoction on the basis of the control group.The clinical efficacy,symptom improvement,the changes in TCM syndrome scores,T-lymphocyte subsets(including CD3+,CD4+,and CD4+/CD8+),inflammatory cytokine levels[including C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)]before and after treatment between the two groups were com-pared.Results:The effective rate of the observation group was 95.12%,which was higher than 78.05%of the control group,and the difference was statistically significant(P<0.05).After treatment,the TCM syndrome scores,TNF-α,CRP,and IL-6 of the two groups were lower than those before treatment,and the observation group's above indexes were lower than those of the control group(P<0.05);the levels of CD3+,CD4+,and CD4+/CD8+in the two groups were higher than those before treatment,and the observation group's above indexes were higher than those of the control group(P<0.05).The observation group had a shorter recovery time for body temperature and disappearance time for cough,sputum,and lung rales compared to the control group(P<0.05).Conclusion:The combination of Supplemented Ephedra and Apricot Kernel and Gypsum and Licorice Decoction and conventional Western medicine can improve the clinical symptoms of acute bronchitis in children,promote the disappearance of cough and sputum symptoms,restore normal body temperature,and enhance the immune function of the body.

申燕燕;耿玉安

郑州市中医院,河南 郑州 450000河南省直第三人民医院,河南 郑州 450000

中医学

小儿急性支气管炎麻杏石甘汤中西医结合疗法《伤寒论》张仲景

acute bronchitis in childrenEphedra and Apricot Kernel and Gypsum and Licorice Decoctionintegrated traditional Chinese and Western medicine therapyTreatise on Cold Damage DiseasesZhang Zhongjing

《河南中医》 2024 (008)

1164-1168 / 5

河南省医学科技攻关计划项目(2018020580)

10.16367/j.issn.1003-5028.2024.08.0214

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