红外与毫米波学报2024，Vol.43Issue(3)：346-355,10.DOI:10.11972/j.issn.1001-9014.2024.03.008
多孔中药固体片剂孔隙率的太赫兹有效介质模型研究
Terahertz study on the porosity of porous traditional Chinese medicine tablets by effective medium models
摘要
Abstract
Generally,the porosity of traditional Chinese medicine is measured by the destructive method of density mea-surement,but there is a lack of non-destructive quantification methods.As one important non-destructive method,tera-hertz radiation has been used to non-destructively extract the drugs'time-domain and frequency-domain optical informa-tion.For direct compression traditional Chinese medicine tablets,the effective refractive index of various tablets was obtained by different methods of terahertz time-domain signal processing and frequency-domain signal processing.It was found that the effective refractive indices with either signal processing method show a good linear relationship with the porosities of the tablets.The porosity of Puerariae Lobatae Radix tablets was extracted and modeled by linear regres-sion based on four effective medium theory models.The porosity regression model based on the effective refractive in-dex by time-domain signal processing shows better performance on the model interpretation and cross-validation accura-cy,with the best model of the Bruggeman model(RPD=11.3325).It provides support for the process optimization of porous powder preparation of traditional Chinese medicine.关键词
太赫兹光谱/有效折射率/有效介质理论/中药片剂孔隙率Key words
Terahertz spectroscopy/effective refractive index/effective medium theory/the porosity of traditional Chinese medicine tablet分类
数理科学引用本文复制引用
李旭,张梦圆,赵雯玥,左剑,朱卫丰,李哲,施宇蕾,张存林..多孔中药固体片剂孔隙率的太赫兹有效介质模型研究[J].红外与毫米波学报,2024,43(3):346-355,10.基金项目
国家自然科学基金(11204190,82003953,12174272) Supported by the National Natural Science Foundation of China(11204190,82003953,12174272). （11204190,82003953,12174272）
