家畜生态学报2024，Vol.45Issue(8)：16-21,6.DOI:10.3969/j.issn.1673-1182.2024.08.003
HMX1基因多态性与绵羊先天小耳畸形的相关性分析
Correlation Analysis Between HMX1 Gene Polymorphism and Congenital Small Ear Deformity in Sheep
摘要
Abstract
In order to study the relationship between SNPs polymorphism of HMX1 gene and its en-hancer mutation and the ovine congenital microtia of sheep,the polymorphism of enhancer and exon in HMX1 gene of 170 Altay sheep was detected by agarose gel electrophoresis combined with PCR sequen-cing technology.The results showed that 24 SNPs were found in exon 1 and exon 2 of HMX1 gene,and A557T was significantly associated with congenital microtia in sheep(P＜0.05);76bp replication was found in HMX1 gene enhancer,which was significantly associated with congenital microtia in sheep(P＜0.01).The results showed that the replication of 76 bp in enhancer of HMX1 gene is the causal mutation of congenital microtia in Altay sheep,which could be used as a molecular marker to eliminate congenital microtia in Altay sheep.关键词
阿勒泰羊/先天小耳畸形/HMX1基因/SNP/增强子Key words
Altay sheep/congenital microtia/HMX1 genes/SNP/enhancer分类
农业科技引用本文复制引用
任亭亭,任思睿,韩冰,蒋芳芳,刘明军,贺三刚..HMX1基因多态性与绵羊先天小耳畸形的相关性分析[J].家畜生态学报,2024,45(8):16-21,6.基金项目
国家自然科学基金项目(31960651) （31960651）
