基础医学与临床2024，Vol.44Issue(8)：1074-1079,6.DOI:10.16352/j.issn.1001-6325.2024.08.1074
肺动脉高压代谢组学:从病理机制到治疗靶点
Metabolomics of pulmonary hypertension:from pathological mechanisms to therapeutic targets
摘要
Abstract
Pulmonary hypertension(PH)is a severe cardiovascular disease characterized primarily by pulmonary vascular remodeling.Patients with PH typically exhibit significant metabolic abnormalities including disruptions in energy metabolism,alterations in lipid and amino acids metabolism.These metabolic disturbances are closely linked to pathophysiological processes such as pulmonary vascular remodeling,endothelial dysfunction and right ventricular hypertrophy.In recent years,there has been rapid progress in the field of metabolomics related to PH.From the early identification of differential metabolic products to the current exploration of potential therapeutic tar-gets,metabolomics has deepened the understanding of the pathogenesis of PH.These researches have accelerated the discovery and screening of potential therapeutic targets,with some findings already translated into clinical prac-tice to support diagnosis,treatment and prognostic evaluation of PH.关键词
代谢组学/肺动脉高压Key words
metabolomics/pulmonary hypertension分类
医药卫生引用本文复制引用
邓渊瑞,王晓建..肺动脉高压代谢组学:从病理机制到治疗靶点[J].基础医学与临床,2024,44(8):1074-1079,6.基金项目
国家自然科学基金面上项目(82170408) （82170408）
北京市自然科学基金(7222142) （7222142）
中央级公益性科研院所基本科研业务费(2020-PT320-005) （2020-PT320-005）
中国医学科学院阜外医院高水平医院临床科研攻关项目(2023-GSP-GG-24) （2023-GSP-GG-24）
心血管疾病国家重点实验室青年项目(2023QN-01) （2023QN-01）
