基础医学与临床2024，Vol.44Issue(8)：1080-1087,8.DOI:10.16352/j.issn.1001-6325.2024.08.1080
炎性细胞与动脉性肺动脉高压血管重塑
Inflammatory cells and vascular remodeling in pulmonary arterial hypertension
摘要
Abstract
Pulmonary arterial hypertension(PAH)is a severe and progressive pulmonary vascular disease mainly characterized by a continuous increase in pulmonary vascular resistance and rise of pulmonary artery pressure caused by pulmonary arteriolar lesions,ultimately resulting in right heart failure and even death.Pulmonary vascular remodeling is a characteristic pathological change of PAH,and its mechanism involves gene susceptibility,imbalance of vasoactive substances,abnormal energy metabolism and other potential factors.Recent studies have found that inflammatory reaction plays a crucial role in the mechanism of pulmonary vascular remodeling.Inflamma-tory cells are found to infiltrate and accumulate around the pulmonary vessels of PAH patients and of animal models.In addition,significantly high level of cytokines and auto-antibodies were also found in peripheral blood,which is closely related to poor prognosis of PAH.This article reviews the research progress about the potential role of in-flammatory cells in the vascular remodeling of PAH and provides new ideas for developing of safe and effective treatment methods for PAH.关键词
动脉性肺动脉高压/肺血管重塑/炎性反应/炎性细胞Key words
pulmonary arterial hypertension/pulmonary vascular remodeling/inflammation/inflammatory cells分类
医药卫生引用本文复制引用
钱喜锋,华潞..炎性细胞与动脉性肺动脉高压血管重塑[J].基础医学与临床,2024,44(8):1080-1087,8.基金项目
中国医学科学院医学与健康科技创新工程项目(2022-I2M-C&T-B-040) （2022-I2M-C&T-B-040）
中国医学科学院阜外医院深圳医院国家心血管疾病临床医学研究中心(深圳)自主课题(NCRCSZ-2023-015) （深圳）
