基础医学与临床2024，Vol.44Issue(8)：1165-1169,5.DOI:10.16352/j.issn.1001-6325.2024.08.1165
MBD2通路在重症哮喘中作用的研究进展
Progress on the role of MBD2 pathway in severe asthma
摘要
Abstract
Severe asthma is a chronic inflammatory disease that is not sensitive to glucocorticoid treatment.In the pathogenesis of severe asthma,T helper cell 17(Th 17)and interleukin 17(IL-17)play an important role,mainly by aggregating the infiltration of neutrophil to aggravate the severity of asthma.Methyl-CpG-binding protein 2(MBD2)plays an important role in the differentiation of Th 17 cells from naive CD4+T cells,positively regulate Th17 differentiation and IL-17 expression.MBD2 binds to the CpG islands in the promoter region of interferon regu-latory factor 4(IRF4),suppressor of cytokine signaling 3(S0CS3),hypoxia-inducible factor-1α(HIF-1α)and misshapen like kinase 1(MINK1),which leads to methylation,regulates the differentiation of Th 17 cells,and par-ticipates in the pathogenesis of severe asthma.关键词
重症哮喘/甲基-CpG结合域蛋白2(MBD2)/辅助性T细胞17Key words
severe asthma/methyl-CpG binding domain protein 2(MBD2)/T helper 17 cells分类
医药卫生引用本文复制引用
吴定将,张秀峰..MBD2通路在重症哮喘中作用的研究进展[J].基础医学与临床,2024,44(8):1165-1169,5.基金项目
国家自然科学基金(81960006) （81960006）
