基础医学与临床2024，Vol.44Issue(8)：1170-1174,5.DOI:10.16352/j.issn.1001-6325.2024.08.1170
CD27/CD70与特发性肺纤维化
CD27/CD70 and idiopathic pulmonary fibrosis
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)is a chronic interstitial lung disease marked by the significant in-volvement of fibroblasts,macrophages and lymphocytes.The CD27/CD70 axis is pivotal in shaping the immune mi-croenvironment present in the fibrotic aeras of lungs.This mentioned interaction involves molecular pathways that work in tandem with lung immune cells,particularly exerting a suppressive influence in the early phases of pulmo-nary fibrosis.Consequently,the CD27/CD70 axis presents a promising new target for immunotherapy in IPF.关键词
特发性肺纤维化/CD27/CD70轴/PI3K/AKT通路Key words
idiopathic pulmonary fibrosis/CD27/CD70 axis/PI3K/AKT pathway分类
医药卫生引用本文复制引用
徐云聪,郑金旭..CD27/CD70与特发性肺纤维化[J].基础医学与临床,2024,44(8):1170-1174,5.基金项目
镇江市重大(社会发展)项目(SH2018048) （社会发展）
苏州市社会发展(民生医疗)项目(SYSD2020010):江苏大学医教协同创新基金(JDYY2023034) （民生医疗）
