基础医学与临床2024，Vol.44Issue(8)：1180-1184,5.DOI:10.16352/j.issn.1001-6325.2024.08.1180
星形胶质细胞吞噬作用在阿尔茨海默病中的研究进展
Research progress of astrocyte phagocytosis in Alzheimer's disease
摘要
Abstract
Astrocytes are heavily activated in Alzheimer's disease,engulfing damaged synapses,Aβ proteins,Tau proteins,apoptotic cells and other substrates.However,these substrates are difficult to degrade,accumulate as the disease progresses,and impair the phagocytosis of astrocytes.During phagocytosis,astrocytes recognize different substrates through a variety of phagocytosis receptors and partially degrade the substrates through degrad-ing enzymes and lysosomal pathways.The accumulation of Aβ and Tau proteins in astrocytes caused astrocyte im-mune and metabolic disorders,and Aβ toxicity changed after phagocytosis.In addition,astrocytes and microglia form a complementary pattern and cooperate to complete phagocytosis through interaction.Regulating the pathway of astrocyte phagocytosis and degradation is believed to be a potential novo therapeutic for clinical treatment of Alzheimer's disease.关键词
星形胶质细胞/吞噬作用/阿尔茨海默病Key words
astrocytes/phagocytosis/Alzheimer's disease分类
医药卫生引用本文复制引用
秦晓莉,赵琳娜,付榕,郭玉莹,徐士欣..星形胶质细胞吞噬作用在阿尔茨海默病中的研究进展[J].基础医学与临床,2024,44(8):1180-1184,5.基金项目
天津市教委科研计划项目(2021KJ146) （2021KJ146）
