中国当代医药2024，Vol.31Issue(18)：29-33,5.
经鼻高流量湿化氧疗对支气管扩张急性加重并Ⅱ型呼吸衰竭患者血气分析和肺功能的影响
Effect of high-flow nasal cannula oxygen therapy on blood gas analysis and pulmonary function in patients with acute exacerbation of bronchiec-tasis and type Ⅱ respiratory failure
摘要
Abstract
Objective To explore the effect of high-flow nasal cannula oxygen therapy(HFNC)combined with conventional therapy on blood gas analysis and pulmonary function in patients with acute exacerbation of bronchiectasis and type Ⅱ res-piratory failure.Methods A total of 40 patients with acute exacerbation of bronchiectasis and type Ⅱ respiratory failure ad-mitted to the Department of Respiratory and Critical Care Medicine,Guangxi Zhuang Autonomous Region National Hospital from July 2020 to January 2023 were selected as the study objects,and they were divided into traditional oxygen therapy group(20 cases)and HFNC group(20 cases)according to random number table method.The traditional oxygen therapy group was treated with nasal catheter,and the HFNC group was treated with HFNC.The changes of arterial blood gas analysis indexes(arterial partial pressure of oxygen[PaO2],arterial partial pressure of carbon dioxide[PaCO2]and Oxygena-tion index[PaO2/FiO2])were compared in the two groups before treatment,2 and 24 hours after treatment and before dis-charge.The changes of pulmonary function indexes(forced expiratory volume in one second[FEVi],the percentage of forced expiratory volume in one second[FEVi％],forced vital capacity[FVC],forced expiratory volume in one second/forced vital capacity[FEV1/FVCJ)and modified British Medical Re-search Council(mMRC)dyspnea questionnaire scores before and after treatment were compared in the two groups.Results At 2 hours,24 hours after treatment and before discharge,the PaO2 and PaO2/FiO2 of two groups were higher than those before treatment in the same group,and the PaO2 and PaO2/FiO2 in the HFNC group were higher than those in the traditional oxygen therapy group,and the differences were statistically significant(P＜0.05).At 24 hours after treatment and before discharge,the PaCO2 of the traditional oxygen therapy group was lower than that before treatment of the same group,and the difference was statistically significant(P＜0.05).At 2 hours,24 hours and before discharge,the PaCO2 of HFNC group was lower than that before treatment in the same group,and the PaCO2 in the HFNC group was lower than that in the traditional oxygen therapy group,and the differences were statistically significant(P＜0.05).Before discharge,the FEV1,FEV1％,FVC,and FEVi/FVC in two groups were higher than those before treatment in the same group,and the FEV1,FEV1％,FVC,and FEV1/FVC in the HFNC group were higher than those in the traditional oxygen therapy group,and the differences were statistically significant(P＜0.05).Before dis-charge,the mMRC scores of two groups were lower than those before treatment in the same group,and the mMRC score in the HFNC group was lower than that in the traditional oxygen therapy group,and the differences were statistically significant(P＜0.05).Conclusion HFNC is effective in the treatment of patients with acute exacerbation of bronchiectasis and type Ⅱrespiratory failure.Compared with traditional oxygen therapy,HFNC can improve the blood gas analysis index and lung function index of patients faster and better,and alleviate the symptoms of dyspnea.关键词
经鼻高流量湿化氧疗/支气管扩张/呼吸衰竭/血气分析/肺功能Key words
High-flow nasal cannula oxygen therapy/Bronchiectasis/Respiratory failure/Blood gas analysis/Pul-monary function分类
医药卫生引用本文复制引用
蓝露莹,张瑜荣,向永红,李美爱,卢肖美..经鼻高流量湿化氧疗对支气管扩张急性加重并Ⅱ型呼吸衰竭患者血气分析和肺功能的影响[J].中国当代医药,2024,31(18):29-33,5.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200357). （Z20200357）
