常州大学学报（自然科学版）2024，Vol.36Issue(4)：8-15,8.DOI:10.3969/j.issn.2095-0411.2024.04.002
钯催化连续亚胺/羰基化构建异喹啉酮四环化合物
Palladium-catalyzed cascade imidoylation/carbonylation to construct isoquinolinone tetracyclic compounds
胡华安子 1刘健 2邱琳 1周舒文 1崔朋飞 1王程 1蒋鹏举 1王建浩1
作者信息
- 1. 常州大学药学院,江苏常州 213164
- 2. 常州恒邦药业有限公司,江苏常州 213001
- 折叠
摘要
Abstract
Using 1,3-bis(2-iodoaryl)propane-2-amines as substrates,a palladium-catalyzed sequen-tial insertion of isocyanide and carbon monoxide to construct isoquinolinone skeletons has been devel-oped.Compared with isoelectronic isocyanide counterparts,the migratory insertion of isocyanide to Ar-Pd(Ⅱ)is still prefer to carbon monoxide although carbon monoxide exists in large excess in the reaction.Followed by carbon monoxide insertion and finally reductive elimination,the corresponding isoquinolinone tetracyclic compounds were obtained.The reaction conditions were mild and the yields are up to 85％.The product was correctly identified by1H NMR,13C NMR and high-resolution mass spectrometry.关键词
亚胺/羰基化/异腈/一氧化碳/异喹啉酮Key words
imidoylation/carbonylation/isocyanide/carbon monoxide/isoquinolinone分类
化学化工引用本文复制引用
胡华安子,刘健,邱琳,周舒文,崔朋飞,王程,蒋鹏举,王建浩..钯催化连续亚胺/羰基化构建异喹啉酮四环化合物[J].常州大学学报（自然科学版）,2024,36(4):8-15,8.
