常州大学学报（自然科学版）2024，Vol.36Issue(4)：71-81,11.DOI:10.3969/j.issn.2095-0411.2024.04.009
天然高分子基角膜修复材料力学性能研究进展
Research progress on mechanical properties of natural polymer based corneal repair materials
摘要
Abstract
Due to the large number of blind individuals and the shortage of donor corneas available for transplantation,artificial corneas have gradually become a research hotspot.However,artificial cor-neas often experience implant tearing due to insufficient mechanical properties.In order to solve this problem,researchers at home and abroad have tried to improve the mechanical properties of corneal repair materials by a series of research work.This paper summarizes the progress relating to the me-chanical properties of four common natural polymer-based corneal repair materials,namely collagen,gelatin,silk fibroin,and chitosan.The results show that physical methods such as photo-crosslinking and thermal crosslinking,chemical methods such as 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide(EDC)/N-hydroxysuccinimide(NHS)crosslinking,genipine or glutaraldehyde crosslinking and other composite methods can significantly improve the mechanical properties of corneal materials,but these methods still have some shortcomings.Therefore,further development of high-quality artificial corne-as is crucial.It is hoped that the article can provide some reference and ideas for the study of impro-ving the mechanical properties of corneal repair materials through summarization.关键词
角膜修复/天然高分子材料/组织工程/人工角膜/力学性能Key words
corneal repair/natural polymer material/tissue engineering/artificial cornea/mechanical properties分类
医药卫生引用本文复制引用
刘杨,张传蕾,孔彦惠,刘慧玉,任天,刘潇,丁硕秋..天然高分子基角膜修复材料力学性能研究进展[J].常州大学学报（自然科学版）,2024,36(4):71-81,11.基金项目
国家自然科学基金资助项目(81900814) （81900814）
江苏省科技厅自然科学基金面上资助项目(BK20171196) （BK20171196）
浙江省重点研发计划资助项目(2020C03003). （2020C03003）
