常州大学学报（自然科学版）2024，Vol.36Issue(4)：82-92,11.DOI:10.3969/j.issn.2095-0411.2024.04.010
负载新吲哚菁绿的还原响应性聚合物胶束增强肿瘤光动力治疗
New indocyanine green-loaded reduction responsive polymeric micelles for enhanced cancer photodynamic therapy
摘要
Abstract
In this study,disulfide bonded methoxypolyethylene glycol-cholesterol conjugates mPEG5000-SS-CH and mPEG2000-SS-CH were synthesized.The two types of IR820-loaded micelles,IR820@mPEG5000-SS-CH and IR820@mPEG2000-SS-CH,which might significantly improve the stability of IR820 in physiological environment,were prepared by solvent diffusion method.While vitro studies show that both mPEG5000-SS-CH and mPEG2000-SS-CH have reduction-responsive re-lease characteristics and good biocompatibility,IR820@mPEG2000-SS-CH displays enhanced cellular uptake and photodynamic killing effect on tumor cells as compared to free IR820 and IR820@mPEG5000-SS-CH.The study suggests that IR820@mPEG2000-SS-CH could be a new choice with superior stability and cancer photodynamic therapeutic effect to IR820.关键词
新吲哚菁绿/光动力治疗/聚乙二醇/胆固醇/胶束/还原响应性Key words
new indocyanine green/photodynamic therapy/polyethylene glycol/cholesterol/micelles/reduction responsiveness分类
医药卫生引用本文复制引用
胡航,肖文,陶亚宇,杜坤达,袁晓音,徐德锋..负载新吲哚菁绿的还原响应性聚合物胶束增强肿瘤光动力治疗[J].常州大学学报（自然科学版）,2024,36(4):82-92,11.基金项目
江苏省高等学校自然科学研究面上资助项目(20KJB350005) （20KJB350005）
常州市重点研发计划资助项目(CJ20210030). （CJ20210030）
