检验医学与临床2024，Vol.21Issue(14)：1991-1995,5.DOI:10.3969/j.issn.1672-9455.2024.14.002
外周血炎症标志物对视网膜静脉阻塞性黄斑水肿的预测价值
Predictive value of peripheral blood inflammatory markers in retinal vein occlusion-related macular edema
摘要
Abstract
Objective To investigate the predictive value of peripheral blood inflammatory markers on the occurrence of retinal vein occlusive macular edema(RVO-ME),and to find the inflammatory biomarkers for predicting the occurrence of RVO-ME.Methods A total of 87 patients with RVO-ME visiting in the ophthal-mology department of this hospital from August 2020 to December 2023 served as the case group,and 87 pa-tients undergoing cataract surgery during the same period were selected as the control group.The patients in the case group were divided into the CRVO subgroup and BVRO subgroup according to the different occlusion positions.The peripheral blood platelet to lymphocyte ratio(PLR),monocyte to lymphocyte ratio(MLR)and neutrophils to lymphocytes ratio(NLR)were compared between the two groups,and the receiver operating characteristic(ROC)curve was used to evaluate the predictive value of peripheral blood PLR,MLR,NLR for the occurrence of RVO-ME.Results The peripheral blood PLR,MLR and NLR in the case group were higher than those in the control group,and the differences were statistically significant(P＜0.05).But there were no statistically significant differences in PLR,MLR and NLR between the BRVO subgroup and CRVO subgroup.The ROC curve analysis results showed that MLR[the area under the curve(AUC)=0.727,95％CI:0.651-0.803)]had better predictive value for RVO-ME occurrence.Conclusion The peripheral blood inflammatory markers PLR,MLR and NLR are closely correlated to the occurrence of RVO-ME.MLR had good predictive value for RVO-ME occurrence and may become as a inflammation biomarker to predict the occurrence RVO-ME.关键词
视网膜静脉阻塞/黄斑水肿/血小板与淋巴细胞比值/单核细胞与淋巴细胞比值/中性粒细胞与淋巴细胞比值/生物标志物Key words
retinal vein occlusion/macular edema/platelet to lymphocyte ratio/monocyte to lym-phocyte ratio/neutrophils to lymphocytes ratio/biomarker分类
医药卫生引用本文复制引用
王继芳,梁凤鸣..外周血炎症标志物对视网膜静脉阻塞性黄斑水肿的预测价值[J].检验医学与临床,2024,21(14):1991-1995,5.基金项目
国家中医药管理局基金项目(中医药循证能力建设2019XZZX-YK012). （中医药循证能力建设2019XZZX-YK012）
