检验医学与临床2024，Vol.21Issue(14)：2011-2015,5.DOI:10.3969/j.issn.1672-9455.2024.14.006
卵裂期胚胎发育速度对体外受精-胚胎移植临床结局的影响
Effect of cleavage stage embryonic development rate on clinical outcomes of in vitro fertilization-embryo transfer
摘要
Abstract
Objective To investigate the effects of cleavage stage embryos with different development rates on subsequent blastocyst culture and clinical outcomes after transfer.Methods The clinical data of the pa-tients with in vitro fertilization-embryo transfer/intracytoplasmic sperm injection assisted pregnancy in the Reproductive Center of this hospital from January 2020 to July 2023 were analyzed retrospectively.They were divided into the 6-10 cells group and 11-16 cells group according to the number of embryonic blastomeres on 3 d.The 6-10 cells group was divided into the 6 cells,7 cells,8 cells,9 cells and 10 cells subgroups.The 11-16 cells group was divided into the 11-12 cells,13-14 cells and 15-16 cells subgroups.The culture situa-tion of blastocyst and the clinical outcomes after transfer were compared among various groups.Results The non-diploid cleavage rate and blastomere fragmentation rate in the 11-16 cells group were significantly higher than those in the 6-10 cells group(P＜0.05).The blastocyst formation rate and high quality blastocyst rate in the 6-10 cells group were significantly lower than those in the 11-16 cells group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the clinical pregnancy rate,embryo implantation rate,abortion rate,live birth rate and baby taking home rate between the two groups(P＞05).In the 6-10 cells subgroup,the blastocyst formation rate in the 6 cells group was signifi-cantly lower than that in the other groups,and the difference was statistically significant(P＜0.05).The blastocyst formation rate in the 7 cells group was significantly lower than that in the 8 cells,9 cells and 10 cells groups(P＜0.05).The high quality blastocyst rate in the 6 cells and 7 cells groups was significantly lower than that in the 8 cells,9 cells and 10 cells groups,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in clinical pregnancy rate,embryo implantation rate,a-bortion rate,live birth rate and baby taking home rate among all groups(P＞0.05).In the 11-16 cells sub-groups,there was no statistically significant difference in blastocyst formation rate,high quality blastocyst rate,clinical pregnancy rate,embryo implantation rate,abortion rate,live birth rate and baby taking home rate among the three groups(P＞0.05).Conclusion 11-16 cells embryos with faster development rate could form the high-quality blastocysts and achieve better clinical outcomes after transfer.关键词
卵裂球数目/发育潜能/囊胚/临床结局/体外受精-胚胎移植Key words
number of embryo blastomere/developmental potential/blastocyst/clinical outcomes/in vitro fertilization-embryo transfer分类
医药卫生引用本文复制引用
纪冰,马学工,李晓娜,吕金春..卵裂期胚胎发育速度对体外受精-胚胎移植临床结局的影响[J].检验医学与临床,2024,21(14):2011-2015,5.基金项目
青海省卫生健康委员会指导性科研课题(2020-wjzdx-31). （2020-wjzdx-31）
