检验医学与临床2024，Vol.21Issue(14)：2020-2024,5.DOI:10.3969/j.issn.1672-9455.2024.14.008
血清IL-35、SDF-1在儿童腹型过敏性紫癜诊断中的临床意义
Clinical significance of serum IL-35 and SDF-1 in diagnosis of abdominal Henoch-Schonlein purpura in children
摘要
Abstract
Objective To explore the clinical significance of serum interleukin-35(IL-35)and stromal cell derived factor-1(SDF-1)in the diagnosis of abdominal Henoch-Schonlein purpura(HSP)in children.Methods A total of 160 children patients with HSP treated in this hospital from February 2018 to February 2020 were selected as the study subjects and divided into the abdominal HSP group(80 cases)and other types of HSP group(80 cases)according to whether or not being abdominal HSP.According to the early disease condition of abdominal HSP,the children patients were divided into the mild group(26 cases),moderate group(26 cases)and severe group(28 cases).Eighty healthy children were selected as the control group.The enzyme linked immunosorbent assay was applied to detect serum IL-35 and SDF-1 levels;the correlation between ser-um IL-35 and SDF-1 levels in children patients with abdominal HSP was analyzed by Pearson method.The multivariate Logistic regression was adopted to analyze the influencing factors of abdominal HSP occurrence;the receiver operating characteristic(ROC)curve was adopted to analyze the diagnostic value of serum IL-35 and SDF-1 in abdominal HSP.Results The serum IL-35 level in the abdominal HSP group was significantly lower than that in other types of HSP group and control group(P＜0.05),while the SDF-1 level in the ab-dominal HSP group was significantly higher than that in other types of HSP group and control group(P＜0.05).With the severity of abdominal HSP increase,serum IL-35 level was decreased significantly(P＜0.05),and SDF-1 level was increased significantly(P＜0.05).There was a negative correlation between ser-um IL-35 level and SDF-1 level in children patients with abdominal HSP(r=-0.594,P＜0.05).Increased IL-35 level was a protective factor of the occurrence of abdominal HSP(P＜0.05),and increased SDF-1 level was a risk factor of the occurrence of abdominal HSP(P＜0.05).The areas under the curve(AUC)of serum IL-35,SDF-1 and their combination for diagnosing abdominal HSP were 0.783,0.765 and 0.805 respectively,meanwhile,AUC of the combination of the two indicators for diagnosis was better than the single diagnosis of serum IL-35 and SDF-1.Conclusion Serum IL-35 level is decreased and SDF-1 level is increased in children patients with abdominal HSP.The combined detection of serum IL-35 and SDF-1 could better diagnose ab-dominal HSP in children.关键词
腹型过敏性紫癜/白细胞介素-35/基质细胞衍生因子/诊断/儿童Key words
abdominal Henoch Schonlein purpura/interleukin-35/stromal cell-derived factor 1/di-agnosis/children分类
医药卫生引用本文复制引用
石艳沙,郭玉敏,史凤霞,路冲,陈文华..血清IL-35、SDF-1在儿童腹型过敏性紫癜诊断中的临床意义[J].检验医学与临床,2024,21(14):2020-2024,5.基金项目
河北省医学科学研究课题(20190958). （20190958）
