检验医学与临床2024，Vol.21Issue(14)：2030-2033,4.DOI:10.3969/j.issn.1672-9455.2024.14.010
血清PAPP-A与子宫动脉超声多普勒血流参数的关系及其对早发型子痫前期的预测价值
Relationship between serum PAPP-A and uterine artery ultrasound Doppler blood flow parameters and its predictive value for early onset preeclampsia
摘要
Abstract
Objective To investigate the relationship between serum pregnancy-associated plasma protein-A(PAPP-A)and uterine artery Doppler blood flow parameters and its predictive value of early onset pre-eclampsia(E-PE).Methods A total of 132 patients with E-PE admitted to the hospital from January 2020 to February 2023 were selected as the E-PE group.In addition,75 healthy pregnant women in the hospital during the same period were selected as the control group.The level of serum PAPP-A in the two groups was detec-ted by enzyme-linked immunosorbent assay,and the uterine artery blood flow parameters[pulsatility index(PI),resistance index(RI),and the ratio of uterine artery systolic and diastolic blood flow velocity(S/D)]were detected and compared.Multivariate Logistic regression was used to analyze the risk factors of E-PE.Pearson correlation analysis was used to analyze the correlation between serum PAPP-A and RI,PI and S/D.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of PAPP-A and uterine artery blood flow parameters alone or in combination for the occurrence of E-PE.Results The serum PAPP-A level of the E-PE group was significantly lower than that of the control group,and RI,PI and S/D were significantly higher than those of the control group,and the differences were statistically significant(P＜0.05).Serum PAPP-A was negatively correlated with RI,PI and S/D(r=-0.446,-0.366,-0.524,P＜0.001).Multivariate Logistic regression analysis showed that decreased serum PAPP-A(OR=0.582,95％CI:0.461-0.734)level,increased RI(OR=1.831,95％CI:1.235-2.715),increased PI(OR=1.865,95％CI:1.195-2.909),and increased S/D(OR=2.016,95％CI:1.091-3.723)were the risk factors for E-PE(P＜0.05).The results of ROC curve analysis showed that AUC of serum PAPP-A,RI,PI and S/D in predic-ting the occurrence of E-PE were 0.804,0.763,0.624 and 0.710 respectively,which were smaller than the AUC of combined detection of the four indicators(P＜0.05).Conclusion Serum PAPP-A and uterine artery Doppler blood flow parameters are abnormal in patients with E-PE,PAPP-A is negatively correlated with blood flow parameters.They can be applied to the prediction of E-PE,which is worthy of further clinical re-search and promotion.关键词
妊娠相关血浆蛋白A/子宫动脉血流参数/早发型子痫前期/相关性/预测效能Key words
pregnancy-associated plasma protein-A/uterine artery blood flow parameter/early-onset preeclampsia/correlation/prediction efficiency分类
医药卫生引用本文复制引用
成云云,王茹,张凯..血清PAPP-A与子宫动脉超声多普勒血流参数的关系及其对早发型子痫前期的预测价值[J].检验医学与临床,2024,21(14):2030-2033,4.基金项目
河北省邢台市重点研发计划项目(2022ZC231). （2022ZC231）
