检验医学与临床2024，Vol.21Issue(14)：2116-2120,5.DOI:10.3969/j.issn.1672-9455.2024.14.027
具有特征性免疫表型的KMT2A基因重排婴儿急性淋巴细胞白血病的临床研究
Clinical study of infantile acute lymphoblastic leukemia with characteristic immunophenotype KMT2A gene rearrangement
摘要
Abstract
Objective To investigate the diagnosis,molecular mechanism and potential treatment strategies of acute lymphoblastic leukemia in infants with KMT2A gene rearrangement with characteristic immunophe-notype.Methods The clinical data and detection results of cell morphology,flow cytology,cytogenetics and molecular biology in 1 case of KMT2A gene rearrangement acute infantile pro-B lymphoblastic leukemia were analyzed."MLL-rearranged""KMT2A-rearranged""acute lymphoblastic leukemia"and"infant"served as the key words and the literatures published in the PubMed database during 2020-2023 were retrieved.Results A total of 145 articles were retrieved,and 27 articles were retained finally.By combining with case analysis and literature review,this study mainly focuses on the clinical manifestations,immunophenotype and biological characteristics of infantile KMT2A gene rearrangement early B precursor lymphocyte leukemia,focuses on the study status quo in onset molecular mechanism and treatment of KMT2A gene rearrangement infantile leuke-mia.Conclusion The treatment of KMT2A gene rearrangement infantile leukemia still remains challenging,which needs to continue to in-depth understand the potential biological characteristics and determine the prog-nostic factors of risk stratification as well as more effective treatment strategies.The molecular targeted thera-py and immunotherapy may be the key to improve the outcomes and reduce the treatment-related mortality.关键词
免疫表型/赖氨酸甲基转移酶2A/基因重排/婴儿/淋巴细胞白血病/混合谱系白血病Key words
immunophenotype/KMT2A/gene rearrangement/infantile/lymphoblastic leukemia/mixed lineage leukemia分类
临床医学引用本文复制引用
杨柯,王薇,赵强,邓伟,蔺莉..具有特征性免疫表型的KMT2A基因重排婴儿急性淋巴细胞白血病的临床研究[J].检验医学与临床,2024,21(14):2116-2120,5.基金项目
甘肃省自然科学基金项目(2022JR5RA729) （2022JR5RA729）
甘肃省兰州市科技计划项目(2022-3-17、2022-5-91). （2022-3-17、2022-5-91）
