临床肝胆病杂志2024，Vol.40Issue(7)：1354-1359,6.DOI:10.12449/JCH240712
睡眠障碍与非酒精性脂肪性肝病不同阶段的关联性分析
Association between sleep disorders and different stages of nonalcoholic fatty liver disease
摘要
Abstract
Objective To investigate the association of sleep disorders with the development and progression of nonalcoholic fatty liver disease(NAFLD).Methods A total of 1 868 participants from the health examination cohort and fatty liver cohort of Beijing Friendship Hospital from June 2022 to June 2023 were enrolled as subjects.Related data were collected from all subjects,including age,sex,education level,chronic medical history,and biochemical parameters,and all subjects completed Pittsburgh Sleep Quality Index(PSQI)scale independently.According to the diagnostic criteria,the subjects were divided into non-NAFLD group with 1 122 subjects and NAFLD group with 746 subjects,and according to the stage of progression,the patients in the NAFLD group were further divided into simple fatty liver group(SFL group with 624 subjects)and nonalcoholic steatohepatitis(NASH)group with 122 subjects.A one-way analysis of variance or the Kruskal-Wallis H test was used for comparison of continuous data between three groups.The chi-square test was used for comparison of categorical data between the three groups.The binary Logistic regression analysis was used to investigate the association between sleep factors and NAFLD,and the multinomial Logistic regression analysis was used to investigate the association between sleep factors and the different stages of NAFLD;two multivariate models were constructed for adjustment of potential confounding factors,i.e.,an age-sex adjustment model and a multivariate adjustment model,and the multivariate adjustment model adjusted the factors of age,sex,education level,smoking,diabetes,hypertension,body mass index(BMI),triglyceride(TG),and high-density lipoprotein cholesterol(HDL-C).Results There were significant differences in age,sex,BMI,education level,smoking,diabetes,hypertension,alanine aminotransferase,TG,and HDL-C between the non-NAFLD,SFL,and NASH groups(all P<0.05).There were also significant differences between the three groups in the total score of PSQI scale and the proportion of subjects with a score of 0—3 points for the 7 sleep components(all P<0.05).The multivariate adjustment model showed no significant association between sleep disorders and SFL,while long sleep latency(odds ratio[OR]=4.04,95%confidence interval[CI]:2.33—7.03,P<0.001),short sleep duration(OR=3.53,95%CI:1.83—6.82,P<0.001),and severe sleep disorders(OR=2.96,95%CI:1.48—5.93,P=0.002)were closely associated with the risk of NASH.Conclusion Overall sleep condition and its components of sleep disorders are not significantly associated with the simple fatty liver;however,long sleep latency,short sleep duration,and severe sleep disorders can increase the risk of NASH,which should be taken seriously in clinical practice.关键词
非酒精性脂肪性肝病/睡眠障碍/回归分析Key words
Non-alcoholic Fatty Liver Disease/Sleep Disorders/Regression Analysis引用本文复制引用
赵静洁,赵欣宇,韩超汝,肖开慧,路正昭,秦林燕,许冬,尤红..睡眠障碍与非酒精性脂肪性肝病不同阶段的关联性分析[J].临床肝胆病杂志,2024,40(7):1354-1359,6.基金项目
首都卫生发展科研专项(首发2022-2-20213,首发2022-1-2021) （首发2022-2-20213,首发2022-1-2021）
2023年北京市重大疑难疾病中西医协同攻关项目(2023BJSZDYNJBXTGG-017) （2023BJSZDYNJBXTGG-017）
北京市高层次公共卫生技术人才建设项目(学科骨干-03-40) Capital's Funds for Health Improvement and Research(CFH2022-2-20213,CFH2022-1-2021) （学科骨干-03-40）
Beijing Key Project of Major Disease by Chinese Medicine and Western Medicine(2023BJSZDYNJBXTGG-017) （2023BJSZDYNJBXTGG-017）
Beijing High-level Public Health Technical Personnel Construction Project(Discipline Backbone-03-40) （Discipline Backbone-03-40）
