临床肝胆病杂志2024，Vol.40Issue(7)：1477-1485,9.DOI:10.12449/JCH240729
中药抑制肝细胞癌血管生成的作用机制
Research advances in the mechanism of action of traditional Chinese medicine in inhibiting angiogenesis in hepatocellular carcinoma
摘要
Abstract
Angiogenesis is a key process in the development and progression of hepatocellular carcinoma(HCC)and can provide essential material conditions for the proliferation,invasion,and metastasis of HCC cells.Inhibition of angiogenesis has become a research hotspot in the field of HCC therapy.Traditional Chinese medicine has become a potential drug for HCC therapy due to its characteristics of multiple targets and pathways,enhancing efficacy and reducing toxicity,improving tumor prognosis,and prolonging survival time.Modern studies have confirmed that traditional Chinese medicine can inhibit tumor angiogenesis by inhibiting the expression of angiogenic factors,upregulating the levels of anti-angiogenic factors,inhibiting endothelial cell proliferation,reducing the microvascular density of HCC tissue,and regulating related signaling pathways,and therefore,traditional Chinese medicine has unique advantages in the treatment of HCC.By summarizing related articles in China and globally in recent years,this article analyzes the mechanism of action of traditional Chinese medicine on inhibiting HCC angiogenesis,in order to provide certain theoretical basis and reference for the optimization of HCC treatment strategies in clinical practice.关键词
瘤,肝细胞/血管生成诱导剂/血管生成抑制剂/中草药Key words
Carcinoma,Hepatocellular/Angiogenesis Inducing Agents/Angiogenesis Inhibitors/Drugs,Chinese Herbal引用本文复制引用
李香香,王振,杨星,李素领..中药抑制肝细胞癌血管生成的作用机制[J].临床肝胆病杂志,2024,40(7):1477-1485,9.基金项目
河南省中医管理局科研专项(20-21ZY1011,2022JDZX048) Henan Provincial Administration of Traditional Chinese Medicine Research Project(20-21ZY1011,2022JDZX048) （20-21ZY1011,2022JDZX048）
