临床口腔医学杂志2024，Vol.40Issue(7)：393-397,5.DOI:10.3969/j.issn.1003-1634.2024.07.003
TRPS1在唾液腺肿瘤中的表达及诊断价值
Expression and diagnostic value of TRPS1 in salivary gland tumors
摘要
Abstract
Objective:To investigate the expression of transcriptional inhibitory factor GATA binding gene 1(TRPS1)in benign and malignant salivary gland tumors and its value in differential diagnosis.Methods:The clinicopatholog-ical data of 450 cases of benign and malignant salivary gland tumors were retrospectively analyzed,and the expression of TRPS1 in 170 cases of benign salivary gland tumors and 280 cases of malignant salivary gland tumors was detected by immu-nohistochemistry.The difference of TRPS1 expression in salivary gland tumors with overlapping histological morphology was analyzed and the application value of TRPS1 in differential diagnosis was also explored.Results:TRPS1 was negative in nor-mal parotid acinar cells and glandular duct cells.TRPS1 was weak-moderate or moderately positive in normal submandibular gland and sublingual gland acinar cells and glandular duct cells.In benign salivary gland tumors,the positive rate of TRPS1 was 82.86％in pleomorphic adenoma,diffuse strong positive in myoepithelial cells,negative or weak positive in glandular ep-ithelial cells and eosinophilic cells.In basal-cell adenomas,the positive rate of TRPS1 was 8.00％,basal-like cells were mostly negative or weakly positive,and stromal cells showed moderate or high expression.TRPS1 of Warthin tumors was nega-tive.In salivary gland malignancies,cancer in pleomorphic adenomas,TRPS1 expression was higher in myoepithelial carcino-ma subtype tumor cells than in adenocarcinoma subtype(85.00％vs.55.00％,P＜0.05).In adenoid cystic carcinoma,the positive rate of TRPS1 was 93.33％.In mucoepidermoid carcinoma,the positive rate of TRPS1 was 52.00％.In clear cell car-cinoma,the positive rate of TRPS1 was 6.67％.In low-grade secretory carcinoma,the positive rate of TRPS1 was 3.33％.In acinous cell carcinoma,the positive rate of TRPS1 was only 33.33％.In the differential diagnosis of benign tumors composed of myoepithelial cells and glandular cells,such as pleomorphic adenomas and basal cell glands,TRPS1 expression was higher in pleomorphic adenomas than in basal cell adenomas(82.86％vs.8.00％,P＜0.001),and TRPS1 expression in the latter was mostly located in stromal cells.In the differential diagnosis of adenoid cystic carcinoma and basal cell adenoma,TRPS1 expression was higher in adenoid cystic carcinoma than in basal cell adenoma(93.33％vs.8.00％,P＜0.001).Conclusion:TRPS1 was low expressed in normal salivary gland tissues.In benign salivary gland tumors,the expression was high in pleo-morphic adenoma and low in other tumor types.In salivary gland malignancies,such as carcinomas in the myoepithelial carci-noma subtype of pleomorphic adenomas and adenoid cystic carcinomas,TRPS1 is highly expressed.The expression of TRPS1 is different in different types of salivary gland tumors,which has potential value for clinical differential diagnosis.关键词
TRPS1/唾液腺肿瘤/鉴别诊断/多形性腺瘤/基底细胞腺瘤/腺样囊性癌Key words
TRPS1/Salivary gland tumor/Differential diagnosis/Pleomorphic adenoma/Basal cell adenoma/Ade-noid cystic carcinoma分类
医药卫生引用本文复制引用
刘丽敏,孙晶晶,钱佳骏,张春叶,胡宇华,李江..TRPS1在唾液腺肿瘤中的表达及诊断价值[J].临床口腔医学杂志,2024,40(7):393-397,5.基金项目
上海市"科技创新行动计划"医学创新研究专项项目(22Y11903300) （22Y11903300）
