临床口腔医学杂志2024，Vol.40Issue(7)：419-424,6.DOI:10.3969/j.issn.1003-1634.2024.07.009
COMP在口腔鳞状细胞癌不同区域间质细胞中的表达及临床意义
Regional and mesenchymal cellular expression of COMP in oral squamous cell carcinoma and their signifi-cance
摘要
Abstract
Objective:Expression and clinical significance of cartilage oligomeric matrix protein(COMP)was studied in mesenchymal cells from different regions of oral squamous cell carcinoma(OSCC).Methods:COMP gene expression was first analyzed using the The Cancer Genome Atlas(TCGA)database.Paraffin-embedded sections of 104 OSCC tissues were collected at Nanjing Stomatological Hospital.The sections were stained by immunohistochemistry(IHC)and focused on fibro-blast-like cells(FLCs)and tumor-infiltrating lymphocytes(TILs)at tumor center(TC)and invasive tumor front(ITF)area.Re-sults:TCGA dataset and IHC results showed that the expression level of COMP was significantly higher in OSCC tissues than that in adjacent tissues.Moreover,regional expression analysis suggested that COMP expression in FLCs were higher at ITF than at TC.Chi-square tests revealed that COMP expression in TILs at TC and in FLCs at ITF were associated with relapse,and COMP expression in TILs both at TC and ITF were associated with depth of invasion(DOI).Kaplan-Meier survival anal-ysis indicated that high expression of COMP in FLCs at IFT and in TILs at TC significantly associated with poor survivals of OSCC patients.Cox regression analysis illustrated that high expression of COMP in FLCs at IFT significantly associated with reduced disease-free survival(DFS).Conclusion:High expression of COMP in FLCs at invasive tumor front area could be an independent risk factor affecting prognosis of OSCC patients.关键词
软骨寡聚基质蛋白/肿瘤中心/浸润前沿/成纤维样细胞/肿瘤浸润淋巴细胞Key words
Cartilage oligomeric matrix protein(COMP)/Tumor center/Invasive tumor front/Fibroblast-like cells/Tumor-infiltrating lymphocytes分类
临床医学引用本文复制引用
陆展翼,泥艳红,胡勤刚..COMP在口腔鳞状细胞癌不同区域间质细胞中的表达及临床意义[J].临床口腔医学杂志,2024,40(7):419-424,6.基金项目
国家自然科学基金项目(82173159) （82173159）
