中国临床保健杂志2024，Vol.27Issue(3)：319-322,4.DOI:10.3969/J.issn.1672-6790.2024.03.007
球囊扩张联合导管接触溶栓治疗下肢深静脉血栓形成的效果
The effect of balloon dilation combined with catheter-directed thrombolysis on deep venous thrombosis of the lower extremities
摘要
Abstract
Objective To explore the effect of balloon dilation combined with catheter-directed thrombolysis(CDT)in the treatment of deep venous thrombosis(DVT)of the lower extremities.Methods The clinical data of 41 patients with DVT who received CDT treatment in the department of vascular surgery,Tongling People's Hospital from November 2017 to December 2023 were retrospectively analyzed.According to whether balloon dilatation was used during the operation,the patients were divided into the observation group(balloon dilatation combined with CDT,n=20)and the control group(CDT alone,n=21).The differences in the efficacy of the two groups were evaluated by comparing the amounts of urokinase used,thrombolysis time,hospitalization days,time to peak fibrinogen decline,thrombolysis success rate,thrombus removal time,Villalta score,changes in fibrinogen and venous patency,anddema resolution rate.Results Compared with CDT alone,balloon dilatation combined with CDT had a shorter thrombus removal time[3(1,5)months vs 5(3,8)months],P＜0.05.In terms of hospitalization time,urokinase dosage,and thrombolysis time,balloon dilatation combined with CDT were significantly lower than those of CDT alone,P＜0.05,and the time to reach the peak decrease in fibrinogen was significantly shorter than that of CDT alone[(15.45±8.14)h vs(21.71±9.95)h,P＜0.05].During the observation group,there was a linear relationship between the change of fibrinogen and the venous pa-tency rate.Conclusion The combination of balloon dilation and CDT has better thrombolysis efficiency and lower bleeding risk than CDT alone in the treatment of DVT.关键词
静脉血栓形成/血栓溶解疗法/血管成形术,气囊,冠状动脉/尿激酶型纤溶酶原激活物Key words
Venous thrombosis/Thrombolytic therapy/Angioplasty,balloon,coronary/Urokinase-type plasmino-gen activator引用本文复制引用
欧明旭,徐江,汪丹青,金良,王筝,胡杨刚,周固超,王良斌..球囊扩张联合导管接触溶栓治疗下肢深静脉血栓形成的效果[J].中国临床保健杂志,2024,27(3):319-322,4.基金项目
蚌埠医学院自然科学重点项目(2023byzd057) （2023byzd057）
