复方红藤糖浆联合抗菌药物治疗盆腔炎性疾病的效果OACSTPCD
The effect of compound red vine syrup combined with antibiotics in the treatment of pelvic inflammatory diseases
目的 探讨复方红藤糖浆联合抗菌药物治疗盆腔炎性疾病(PID)患者的效果及安全性.方法 选取2018年1月至2021年12月安徽中医药大学第一附属医院妇科收治入院的60例PID患者为研究对象,按随机数字表法分为研究组和对照组,各30例.2组采用盐酸头孢替安联合奥硝唑氯化钠注射液静脉输注治疗,研究组同时予复方红藤糖浆口服,2组均治疗1周.比较2组患者临床疗效、疼痛视觉模拟评分(VAS)、盆腔痛客观体征(McCormack)评分、下腹疼痛、腰骶疼痛、带下异常、乏力中医症候积分、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-10、肿瘤坏死因子(TNF)-α.结果 治疗后,研究组及对照组的总有效率分别为93.33％及73.33％;研究组总有效率高于对照组,差异有统计学意义(P＜0.05).与治疗前相比较,2组治疗后VAS评分、McCormack评分、下腹疼痛积分、腰骶疼痛积分、带下异常积分、乏力积分、WBC、hs-CRP、TNF-α降低,IL-10升高(P均＜0.01).与对照组治疗后相比较,研究组治疗后VAS评分、McCormack评分、下腹疼痛积分、腰骶疼痛积分、带下异常积分、乏力积分、WBC、hs-CRP、TNF-α降低,IL-10升高(P均＜0.05).结论 复方红藤糖浆联合抗菌药物可改善湿热蕴结证盆腔炎患者临床症状,疗效明显.
Objective To explore the clinical efficacy and safety of compound red vine syrup combined with antibiotics in patients with pelvic inflammatory disease(PID).Methods Sixty PID patients admitted to the gynecology department of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2018 to De-cember 2021 were selected as the research subjects.They were randomly divided into a study group and a control group,with 30 patients in each group,using a random number table method.Both groups were treated with intravenous infusion of cefotetan combined with metronidazole sodium chloride injection,with the study group also receiving oral administra-tion of compound red vine syrup.Both groups were treated for 1 week.The clinical efficacy of the two groups of patients was compared,including the Visual Analog Scale(VAS)score for pain,the McCormack objective signs score for pelvic pain,as well as changes in lower back and sacral pain,lower abdominal pain,abnormal vaginal discharge,Traditional Chinese Medicine symptom score for fatigue,white blood cell count(WBC),hypersensitive C-reactive protein(hs-CRP),interleukin(IL)-10,and tumor necrosis factor(TNF)-α in both groups.Results After treatment,the total ef-fective rates in the study group and the control group were 93.33％and 73.33％,respectively.The total effective rate in the study group was higher than that in the control group(P＜0.05).Compared with before treatment,both groups showed decreases in VAS score,McCormack score,lower back and sacral pain score,lower abdominal pain score,abnor-mal vaginal discharge score,fatigue score,WBC count,hs-CRP level,and TNF-αlevel,as well as an increase in IL-10 level(all P＜0.01)after treatment.Compared with the control group after treatment,the study group showed decreases in VAS score,McCormack score,lower back and sacral pain score,lower abdominal pain score,abnormal vaginal dis-charge score,fatigue score,WBC count,hs-CRP level,and TNF-α level,as well as an increase in IL-10 level(all P＜0.05).Conclusions The combination of compound red vine syrup and antibiotics can improve the clinical symptoms of PID patients with damp heat accumulation syndrome which is safe.
熊程俏;李伟莉;储继军;徐云霞;张红;余欣慧
安徽中医药大学第一附属医院妇产科,合肥 230031
盆腔炎性疾病抗菌药炎症湿热中草药
Pelvic inflammatory diseaseAnti-bacterial agentsInflammationDampness heatDrugs,Chinese herbal
《中国临床保健杂志》 2024 (003)
369-373 / 5
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号);安徽省高等学校科学研究项目(2023AH050853)
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