皮肤性病诊疗学杂志2024，Vol.31Issue(7)：464-469,6.DOI:10.3969/j.issn.1674-8468.2024.07.004
2018-2022年438株淋球菌临床分离株耐药性分析
Analysis of antibiotic resistance of 438 clinical isolates of Neisseria gonorrhoeae obtained from 2018 to 2022
摘要
Abstract
Objective To summarize the surveillance results of antibiotic resistance of Neisse-ria gonorrhoeae to 7 antibiotics(penicillin G,tetracycline,ciprofloxacin,spectinomycin,ce-fixime,ceftriaxone and Azithromycin)in Panyu District,Guangzhou,from 2018 to 2022.Meth-ods Neisseria gonorrhoeae strains were isolated from urogenital secretions such as urethra or cer-vical vagina at the sexually transmitted disease outpatient clinic of Panyu District from 2018 to 2022.The agar dilution method was used to determine the minimum inhibitory concentrations(MICs)of the seven antibiotics.Penicillinase-producing N.gonorrhoeae(PPNG)was analyzed by the paper acidometric method.The sensitivity and prevalence of Neisseria gonorrhoeae strains to antibiotics were compared among those years.Results A total of 438 strains of Neisseria gonor-rhoeae were collected.Among them,the rates of PPNG and TRNG were 48.86％(214/438)and 38.13％(167/438),respectively.The overall resistance rates to tetracycline,ciprofloxacin,and azithromycin were 90.18％,96.12％,and 13.47％,respectively.The resistance rate to penicil-lin was increased significantly from 50.60％in 2018 to 84.00％in 2022(x2=23.59,P＜0.01).We found no strains resistant to spectinomycin,ceftriaxone,and cefixime.However,the intermediate sensitivity to ceftriaxone and cefixime was increased from 2.41％(2/83)and 3.61％(3/83)in 2018 to 13.00％(13/100)and 25.00％(25/100)respectively,in 2022(x2=6.76,P＜0.01 and x2=14.39,P＜0.01).Conclusions All Neisseria gonorrhoeae strains collected from 2018 to 2022 are sensitive to erythromycin,ceftriaxone,and cefixime.How-ever,there is a trend of yearly increase in the rates of low-sensitivity to ceftriaxone and cefixime,and PPNG and TRNG are also highly prevalent.关键词
淋病/奈瑟氏球菌/药物监测/微生物敏感性试验/耐药性分析Key words
gonorrhea/Neisseria gonorrhoeae/drug survellance/microbial sensitivity tests/drug resistance analysis引用本文复制引用
梁焕喜,劳丽嫦,黎敬忠,何晓能,黄蕴怡,郭键瑜,郭炽星..2018-2022年438株淋球菌临床分离株耐药性分析[J].皮肤性病诊疗学杂志,2024,31(7):464-469,6.基金项目
番禺区科技计划项目(2021-Z04-107) （2021-Z04-107）
