皮肤性病诊疗学杂志2024，Vol.31Issue(7)：484-488,5.DOI:10.3969/j.issn.1674-8468.2024.07.008
索立德吉治疗基底细胞癌并文献复习
Treatment of basal cell carcinoma with Sonidegib and literature review
贾子悦 1庄哲 1李欣辉 1陈永锋1
作者信息
- 1. 南方医科大学皮肤病医院,广东 广州 510091
- 折叠
摘要
Abstract
Objective To investigate the efficacy and safety of Sonidegib for basal cell carci-noma.Methods Clinical data and skin histology were analyzed in a patient with ulcerated brown plaque on the nasal dorsum.After the diagnosis of basal cell carcinoma,patient was orally given a Hedgehog pathway inhibitor,Sonidegib.Results The patient was diagnosed with basal cell carci-noma.After the treatment with Sonidegib,the skin lesions became flat and ulcers were healed,without the development of new ulcers.Prior to the treatment,patient's liver and muscle enzymes were normal.Following one-week treatment with Sonidegib,the patient experienced muscle weak-ness,loss of appetite,vomiting,fatigue,and drowsiness,with an EGOG level of 3.After 4 weeks of treatment,the liver enzymes and serum CK were 2.5 times over normal levels.Sonidegib was discontinued at week 6 due to his intolerance of side effects.Then the patient was given the Mohs surgery and skin grafting.Conclusions Sonidegib can induce liver damage and musculoskeletal reactions.Adverse reactions should be dynamically monitored in clinical use of this drug.If the tumor is large or direct surgical removal may cause severe trauma,neoadjuvant therapy can be beneficial.In clinic,drugs can be intermittently administered according to patients'tolerance to improve tolerance and adherence.关键词
基底细胞癌/索立德吉/Hedgehog通路抑制剂Key words
basal cell carcinoma/Sonidegib/hedgehog pathway inhibitors引用本文复制引用
贾子悦,庄哲,李欣辉,陈永锋..索立德吉治疗基底细胞癌并文献复习[J].皮肤性病诊疗学杂志,2024,31(7):484-488,5.
