岭南现代临床外科2024，Vol.24Issue(2)：100-105,6.DOI:10.3969/j.issn.1009-976X.2024.02.003
肿瘤浸润淋巴细胞预测乳腺癌新辅助化疗疗效
Tumor infiltrating lymphocytes predict the efficacy of neoadjuvant chemotherapy for breast cancer
摘要
Abstract
Objective To evaluate the infiltration level of tumor infiltrating lymphocytes(TILs)and explore the correlation between TILs and the efficacy of neoadjuvant chemotherapy for breast cancer.Methods A total of 87 cases were included with invasive breast cancer were diagnosed by preoperative biopsy.TILs infiltration evaluated by H&E staining under microscope.The correlation between the expression levels of TILs and clinicopathological features as well as the efficacy of neoadjuvant chemo-therapy was analyzed.Results The expressions of TILs in the preoperative core needle biopsy were closely related to the molecular subtypes of breast cancer,and the expression was highest in the HER2 over-expression and triple negative breast cancer subtypes.TILs level was significantly correlated with the expression of ER,PR and pathological complete response(pCR).TILs level was higher in ER-and PR-patients(P＜0.05).The pCR rate in patients with high TILs infiltration was significantly higher than that in low TILs infiltration(P＜0.05).The pCR rates were also higher in ER-and PR-patients(P＜0.05).Multivariate analysis showed that TILs was an independent predictor for efficacy of neoadjuvant chemotherapy(P=0.041).Conclusion Our study found that TILs was an independent predictor of the efficacy of neoadjuvant chemotherapy.A high TILs lever indicates better therapeutic effect.关键词
乳腺癌/新辅助化疗/肿瘤浸润淋巴细胞Key words
breast cancer/neoadjuvant chemotherapy/tumor infiltrating lymphocytes分类
医药卫生引用本文复制引用
邬慧倩,倪亨吏,周爱君,袁杭,李建明..肿瘤浸润淋巴细胞预测乳腺癌新辅助化疗疗效[J].岭南现代临床外科,2024,24(2):100-105,6.基金项目
国家自然科学基金重点项目(82130080) （82130080）
