西南医科大学学报2024，Vol.47Issue(4)：325-329,5.DOI:10.3969/j.issn.2096-3351.2024.04.010
慢性肾衰竭血液透析患者IL-13、FGF23、SOST水平变化与血管钙化的关系
Changes of serum levels of interleukin-13,fibroblast growth factor 23 and sclerostin in patients with chronic renal failure undergoing hemodialysis and their relationship with vascular calcification
摘要
Abstract
Objective To analyze the changes of serum interleukin-13(IL-13),fibroblast growth factor 23(FGF23)and sclerostin(SOST)levels and their relationship with vascular calcification in patients with chronic renal failure(CRF)undergoing he-modialysis.Methods The clinical data of 126 patients with CRF undergoing maintenance hemodialysis(MHD)admitted to the First Affiliated Hospital of Zhengzhou University from January 2021 to December 2022 were collected.All patients were observed for vascu-lar calcification by X-ray normotopia film and abdominal plain film.According to Adragao calcification score,the patients were divided into 0 points(no calcification),1～3 points(mild calcification),4～6 points(moderate calcification)and 7～8 points(severe calcifi-cation).The diagnostic value of serum IL-13,FGF23 and SOST on vascular calcification was evaluated by receiver operating character-istic(ROC)curve.Pearson correlation coefficient was used to evaluate the correlation between vascular calcification score and serum IL-13,FGF23 and SOST in patients with vascular calcification.Results Among the patients with CRF undergoing MHD,the proportion of diabetes mellitus history in patients with vascular calcification was higher than that in patients without vascular calcification(P<0.05),and the levels of serum IL-13,FGF23 and SOST were higher than those in patients without vascular calcification(P<0.05).ROC curve analysis showed that serum IL-13,FGF23 and SOST had diagnostic value on vascular calcification in patients with CRF un-dergoing MHD(AUCIL-13=0.827,P<0.05;AUCFGF2=0.781,P<0.05;AUCSOST=0.746,P<0.05),and the combination of the three items had the highest diagnostic value(AUC=0.906,P<0.05).Serum levels of IL-13,FGF23 and SOST in patients with severe vas-cular calcification were significantly higher than those in patients with moderate calcification and patients with mild calcification(P<0.05),and the above levels in patients with moderate calcification were higher than those in patients with mild calcification(P<0.05).Pearson correlation coefficient analysis revealed that the vascular calcification score in patients with vascular calcification was posi-tively correlated with serum IL-13,FGF23 and SOST(rIL-13=0.532,P<0.05;rFGF23=0.504,P<0.05;rSOST=0.511,P<0.05).Con-clusion IL-13,FGF23 and SOST may be involved in the occurrence and development of vascular calcification in patients with CRF un-dergoing MHD,and monitoring the changes of serum levels in patients is beneficial for clinical diagnosis and treatment.关键词
慢性肾衰竭/维持性血液透析/血管钙化/血清白介素13/成纤维细胞生长因子23/骨硬化蛋白Key words
Chronic renal failure/Maintenance hemodialysis/Vascular calcification/IL-13/FGF23/SOST分类
临床医学引用本文复制引用
罗静,王琰,张瑞,刘敏,李晓莹..慢性肾衰竭血液透析患者IL-13、FGF23、SOST水平变化与血管钙化的关系[J].西南医科大学学报,2024,47(4):325-329,5.基金项目
河南省科技发展计划项目(202102310226) （202102310226）
